Cristin-resultat-ID: 366958
Sist endret: 25. oktober 2016 14:35
Resultat
Vitenskapelig artikkel
2006

Intestinal adenomas of min-mice lack enterochromaffiin cells, and have increased lysozyme production in non-paneth cells

Bidragsytere:
  • Trine Husøy
  • Helle Katrine Knutsen
  • Else Marit Løberg og
  • Jan Alexander

Tidsskrift

Anticancer Research
ISSN 0250-7005
e-ISSN 1791-7530
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2006
Volum: 26
Hefte: 3A
Sider: 1797 - 1802

Importkilder

Isi-ID: 000238490700010

Beskrivelse Beskrivelse

Tittel

Intestinal adenomas of min-mice lack enterochromaffiin cells, and have increased lysozyme production in non-paneth cells

Sammendrag

BACKGROUND: Adenomatous polyposis coli (APC) are important in maintaining normal epithelial mucosa. Intestinal tissues with mutations in Apc have disturbed cell proliferation, differentiation and migration. Paneth and enterochromaffin cells were studied in the intestine and intestinal adenomas from Min-mice with heterozygote and homozygote mutations in Apc, respectively. MATERIALS AND METHODS: The presence of Paneth and enterochromaffin cells in normal intestine and adenomas from Min-mice was studied in sections stained with lysozyme/PAS and connexin32. RESULTS: Min-mice intestinal adenomas had an increased number of lysozyme-producing Paneth/goblet and non-Paneth cells and a reduced number of enterochromaffin cells. The large intestine had a significantly higher number of enterochromaffin cells than the small intestine and more were seen in the large intestine of Min- compared with wt-mice. CONCLUSION: Altered cell differentiation in adenomas might be caused by different response to Wnt-signalling, while an increased number of enterochromaffin cells in the large intestine is rather an effect of a heterozygous Apc(Min) mutation.

Bidragsytere

Trine Husøy

  • Tilknyttet:
    Forfatter
    ved Avdeling for toksikologi og risiko ved Folkehelseinstituttet

Helle Katrine Knutsen

  • Tilknyttet:
    Forfatter
    ved Avdeling for miljøeksponering og -epidemiologi ved Folkehelseinstituttet

Else Marit Løberg

  • Tilknyttet:
    Forfatter
    ved Patologisk anatomisk avdeling ved Universitetet i Oslo

Jan Alexander

  • Tilknyttet:
    Forfatter
    ved Smittevern, miljø og helse ved Folkehelseinstituttet
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