Cristin-resultat-ID: 400431
Sist endret: 21. oktober 2013, 12:13
Resultat
Vitenskapelig artikkel
2002

Interleukin-7 (IL-7) in patients receiving intensive chemotherapy for acute myelogenous leukemia: studies of systemic IL-7 Levels and IL-7 responsiveness of circulating T lymphocytes

Bidragsytere:
  • Øystein Wendelbo
  • Nils Glenjen og
  • Øystein Bruserud

Tidsskrift

Journal of Interferon and Cytokine Research
ISSN 1079-9907
e-ISSN 1557-7465
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2002
Volum: 22
Hefte: 10
Sider: 1057 - 1065

Importkilder

Fdok-ID: 23620

Beskrivelse Beskrivelse

Tittel

Interleukin-7 (IL-7) in patients receiving intensive chemotherapy for acute myelogenous leukemia: studies of systemic IL-7 Levels and IL-7 responsiveness of circulating T lymphocytes

Sammendrag

Early immune reconstitution after intensive chemotherapy for acute myelogenous leukemia (AML) occurs after 2-4 weeks of cytopenia, but T cell reconstitute is usually completed after several months. Interleukin-7 (IL-7) is a T cell growth factor involved in the late immune reconstitution, but its function during the early period of cytopenia has not been investigated. In the present study, we found that patients with untreated AML had decreased IL-7 serum levels, and induction chemotherapy had divergent effects on these levels. In contrast, patients in complete remission (CR) had intermediate levels immediately before consolidation therapy, and these levels decreased significantly when the patients developed therapy-induced cytopenia. Systemic IL-7 levels showed only minor increases during febrile neutropenia. Furthermore, IL-7 enhanced in vitro proliferative responses of polyclonal T cells derived from cytopenic patients, and the majority of circulating clonogenic CD4(+) and CD8(+) T cells from cytopenic patients could respond to both IL-2 and IL-7. To conclude, patients with untreated AML and severe chemotherapy-induced leukopenia (1) differ from other patients with CD4(+) T lymphopenia in that they show decreased IL-7 serum levels, and (2) the detection of circulating IL7-responsive T cells indicates that variations in systemic IL-7 levels are functionally important and contribute to an additional qualitative T cell defect in these severely T lymphopenic patients.

Bidragsytere

Øystein Wendelbo

  • Tilknyttet:
    Forfatter
    ved Institutt for indremedisin ved Universitetet i Bergen

Nils Glenjen

  • Tilknyttet:
    Forfatter
    ved Institutt for indremedisin ved Universitetet i Bergen

Øystein Bruserud

  • Tilknyttet:
    Forfatter
    ved Institutt for indremedisin ved Universitetet i Bergen
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