Cristin-resultat-ID: 433351
Sist endret: 21. januar 2015 15:27
Resultat
Vitenskapelig artikkel
1998

Effect of aluminium hydroxide and meningoccoccal serogroup C capsular polysaccharide on the immunogenicity and reactogenicity of a group B Neisseria meningitidis outer membrane vesicle vaccine

Bidragsytere:
  • Einar Rosenqvist
  • Ernst Arne Høiby
  • Gunnar Aksel Bjune
  • Audun Aase
  • Anne S. Halstensen
  • A.K. Lehmann
  • mfl.

Tidsskrift

Dev Biol Stand

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 1998
Volum: 92
Sider: 323 - 333

Importkilder

ForskDok-ID: 21502

Beskrivelse Beskrivelse

Tittel

Effect of aluminium hydroxide and meningoccoccal serogroup C capsular polysaccharide on the immunogenicity and reactogenicity of a group B Neisseria meningitidis outer membrane vesicle vaccine

Sammendrag

Three different formulations of an outer membrane vesicle (OMV) vaccine against group B meningococcal disease have been prepared and tested for immunogenicity and reactogenicity in adult volunteers. The vaccines were prepared with or without aluminium hydroxide and serogroup C-polysaccharide (C-ps). Doses from 12.5 to 100 micrograms protein were given twice at a six weeks' interval. All three formulations were well tolerated and highly immunogenic, inducing bactericidal and opsonizing antibodies in humans. Adsorption of OMVs to aluminium hydroxide reduced the pyrogenicity in rabbits. The differences in immunogenicity between the formulations were relatively small, but after the second dose a stronger booster response was observed when the vaccines were adsorbed. Thus, a formulation with OMVs and C-ps represents a safe and highly immunogenic vaccine, even without aluminium hydroxide.

Bidragsytere

Einar Rosenqvist

  • Tilknyttet:
    Forfatter

Ernst Arne Høiby

  • Tilknyttet:
    Forfatter
Aktiv cristin-person

Gunnar Aksel Bjune

  • Tilknyttet:
    Forfatter
    ved Seksjon for internasjonal helse ved Universitetet i Oslo

Audun Aase

  • Tilknyttet:
    Forfatter

Anne S. Halstensen

  • Tilknyttet:
    Forfatter
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