Cristin-resultat-ID: 501074
Sist endret: 6. mai 2009, 16:42
NVI-rapporteringsår: 2009
Vitenskapelig oversiktsartikkel/review

MPB70 and MPB83 - Major Antigens of Mycobacterium bovis

  • Harald G Wiker


Scandinavian Journal of Immunology
ISSN 0300-9475
e-ISSN 1365-3083
NVI-nivå 1

Om resultatet

Vitenskapelig oversiktsartikkel/review
Publiseringsår: 2009
Volum: 59
Hefte: 6
Sider: 492 - 499


Isi-ID: 000265512200004
Scopus-ID: 2-s2.0-65349118783



Medisinsk mikrobiologi

Beskrivelse Beskrivelse


MPB70 and MPB83 - Major Antigens of Mycobacterium bovis


MPB70 and MPB83 are among the most studied mycobacterial antigens. They are highly homologous proteins within Mycobacterium tuberculosis complex members, and the orthologs in different members of the complex are virtually identical. They are major antigens highly expressed by Mycobacterium bovis and considerably less abundantly expressed by M. tuberculosis. There are two genes encoding these proteins within an operon of six genes. MPB70 and MPB83 are encoded as precursor proteins with typical signal peptides for export through the general secretory pathway. MPB70 is a soluble secreted protein cleaved by signal peptidase I, while MPB83 is a glycosylated lipoprotein pro- cessed by signal peptidase II and located at the surface, possibly with the lipid tail coupled to the N-terminal cystein embedded in the mycobacterial outer membrane. The expression of these genes is controlled by the transcriptional regulator SigK, and a point mutation in SigK explains why some Bacille Calmette-Guerin (BCG) strains express only minute amounts of MPB70 and MPB83. BCG strains that have retained the high expression of MPB70 and MPB83 of wild type M. bovis are linked to a risk of BCG osteitis in


Harald Gotten Wiker

Bidragsyterens navn vises på dette resultatet som Harald G Wiker
  • Tilknyttet:
    ved Gades institutt ved Universitetet i Bergen
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