Cristin-resultat-ID: 501710
Sist endret: 28. oktober 2016 16:36
Resultat
Vitenskapelig oversiktsartikkel/review
2007

Outcomes of patients who participate in randomised controlled trials compared to similar patients receiving similar interventions who do not participate (Review)

Bidragsytere:
  • Gunn Elisabeth Vist
  • KB Hagen
  • PJ Devereaux
  • D Bryant
  • Doris Tove Kristoffersen og
  • Andrew David Oxman

Tidsskrift

Cochrane Database of Systematic Reviews
ISSN 1469-493X
e-ISSN 1469-493X
NVI-nivå 1

Om resultatet

Vitenskapelig oversiktsartikkel/review
Publiseringsår: 2007
Hefte: 2
Artikkelnummer: MR000009

Importkilder

Isi-ID: 000245760200099

Beskrivelse Beskrivelse

Tittel

Outcomes of patients who participate in randomised controlled trials compared to similar patients receiving similar interventions who do not participate (Review)

Sammendrag

Background Some people believe that patients who take part in randomised controlled trials (RCTs) face risks that they would not face if they opted for non-trial treatment. Others think that trial participation is beneficial and the best way to ensure access to the most up to date physicians and treatments. Objectives To assess the effects of patient participation in RCTs (’trial effects’) independent both of the effects of the clinical treatments being compared (’treatment effects’) and any differences between patients who participated in RCTs and those who did not. Search strategy In May 2001, we searched The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, The Cochrane Methodology Register, SciSearch and PsycINFO for potentially relevant studies. Our search yielded over 10,000 references. In addition, we reviewed the reference lists of relevant articles and wrote to over 250 investigators to try to obtain further information. Selection criteria Randomised studies and cohort studies with data on clinical outcomes of RCT participants and similar patients who received similar treatment outside of RCTs. Data collection and analysis At least two reviewers independently assessed studies for inclusion, assessed study quality and extracted data. Study authors were contacted for additional information. Main results We included five randomised studies (yielding 6 comparisons) and 50 non-randomised cohort studies (85 comparisons), with 31,140 patients treated in RCTs and 20,380 patients treated outside RCTs. In the randomised studies, patients were invited to participate in an RCT or not; these comparisons provided limited information because of small sample sizes (a total of 412 patients) and the nature of the questions they addressed. There was statistically significant heterogeneity (P

Bidragsytere

Gunn Elisabeth Vist

  • Tilknyttet:
    Forfatter
    ved Avdeling for vurdering av tiltak ved Folkehelseinstituttet
Aktiv cristin-person

Kåre Birger Hagen

Bidragsyterens navn vises på dette resultatet som KB Hagen
  • Tilknyttet:
    Forfatter

PJ Devereaux

  • Tilknyttet:
    Forfatter

D Bryant

  • Tilknyttet:
    Forfatter

Doris Tove Kristoffersen

  • Tilknyttet:
    Forfatter
    ved Avdeling for forskning og analyse av helsetjenesten ved Folkehelseinstituttet
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