Cristin-resultat-ID: 501779
Sist endret: 2. juni 2017 12:08
Resultat
Vitenskapelig oversiktsartikkel/review
2006

Endocrine disruption induced by organochlorines (OCs): Field studies and experimental models

Bidragsytere:
  • Erik Ropstad
  • Irma C. Oskam
  • Jan L. Lyche
  • Hans Jørgen S. Larsen
  • Elisabeth Lie
  • Marte Haave
  • mfl.

Tidsskrift

Journal of Toxicology and Environmental Health, Part A
ISSN 1528-7394
e-ISSN 1087-2620
NVI-nivå 1

Om resultatet

Vitenskapelig oversiktsartikkel/review
Publiseringsår: 2006
Volum: 69
Hefte: 1-2
Sider: 53-76

Importkilder

Isi-ID: 000235147500004

Beskrivelse Beskrivelse

Tittel

Endocrine disruption induced by organochlorines (OCs): Field studies and experimental models

Sammendrag

Long-range transport of persistent organic compounds by air and ocean currents from industrialized areas resulted in high levels of these pollutants in food webs in the Svalbard area. With the aim to test if organochlorine (OC) exposure in free-living polar bears from Svalbard affected their plasma steroid hormone concentrations, it was found that polychlorinated biphenyls (PCBs) were associated with increased progesterone levels in females. The sum of pesticides (sigma pesticides) and sigma PCBs contributed significantly negative to the variation of the plasma testosterone in males, and the overall contribution of the OCs to the plasma cortisol variation was negative. A second objective was to study the effects of selected OCs (i.e., PCB 153 and PCB 126) on animal health as a consequence of effects on endocrine-regulated functions such as reproduction and immunity in a goat model focusing on long-term and low-level exposure during the periods of fetal development and in the neonatal period. Additionally, acute exposure was studied in adult mice. The results indicated that exposure to low doses of PCB 153 in utero and in the suckling period influenced reproductive functions and both PCB 153 and PCB 126 exerted immunomodulatory effects on the offspring, whereas acute exposure of adult mice had minor effects on male reproductive function.

Bidragsytere

Erik Ropstad

  • Tilknyttet:
    Forfatter
    ved Institutt for produksjonsdyrmedisin ved Norges miljø- og biovitenskapelige universitet

Irma C. Oskam

  • Tilknyttet:
    Forfatter
    ved Institutt for produksjonsdyrmedisin ved Norges miljø- og biovitenskapelige universitet

Jan Ludvig Lyche

Bidragsyterens navn vises på dette resultatet som Jan L. Lyche
  • Tilknyttet:
    Forfatter
    ved Institutt for produksjonsdyrmedisin ved Norges miljø- og biovitenskapelige universitet

Hans J. Larsen

Bidragsyterens navn vises på dette resultatet som Hans Jørgen S. Larsen
  • Tilknyttet:
    Forfatter
    ved Institutt for prekliniske fag og patologi ved Norges miljø- og biovitenskapelige universitet

Elisabeth Lie

  • Tilknyttet:
    Forfatter
    ved Kjemi ved Veterinærinstituttet
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