Cristin-resultat-ID: 527637
Sist endret: 1. desember 2011 13:22
NVI-rapporteringsår: 2010
Resultat
Vitenskapelig artikkel
2010

Differential influence of levodopa on reward-based learning in Parkinson's disease

Bidragsytere:
  • Susanne Graef
  • Guido Biele
  • Lea K. Krugel
  • Frank Marzinzik
  • Michael Wahl
  • Johann Wotka
  • mfl.

Tidsskrift

Frontiers in Human Neuroscience
ISSN 1662-5161
e-ISSN 1662-5161
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2010
Volum: 4
Artikkelnummer: 169
Open Access

Importkilder

Isi-ID: 000289308600001

Beskrivelse Beskrivelse

Tittel

Differential influence of levodopa on reward-based learning in Parkinson's disease

Sammendrag

The mesocorticolimbic dopamine (DA) system linking the dopaminergic midbrain to the prefrontal cortex and subcortical striatum has been shown to be sensitive to reinforcement in animals and humans. Within this system, coexistent segregated striato-frontal circuits have been linked to different functions. In the present study, we tested patients with Parkinson’s disease (PD), a neurodegenerative disorder characterized by dopaminergic cell loss, on two reward-based learning tasks assumed to differentially involve dorsal and ventral striato-frontal circuits. 15 non-depressed and non-demented PD patients on levodopa monotherapy were tested both on and off medication. Levodopa had beneficial effects on the performance on an instrumental learning task with constant stimulus-reward associations, hypothesized to rely on dorsal striato-frontal circuits. In contrast, performance on a reversal learning task with changing reward contingencies, relying on ventral striato-frontal structures, was better in the unmedicated state. These results are in line with the “overdose hypothesis” which assumes detrimental effects of dopaminergic medication on functions relying upon less affected regions in PD. This study demonstrates, in a within-subject design, a double dissociation of dopaminergic medication and performance on two reward-based learning tasks differing in regard to whether reward contingencies are constant or dynamic. There was no evidence for a dose effect of levodopa on reward-based behavior with the patients’ actual levodopa dose being uncorrelated to their performance on the reward-based learning tasks.

Bidragsytere

Susanne Graef

  • Tilknyttet:
    Forfatter
    ved Max-Planck-Institut für Bildungsforschung
  • Tilknyttet:
    Forfatter
    ved Max-Planck-Institut für Kognitions- und Neurowissenschaften
Aktiv cristin-person

Guido Philipp Emmanuel Biele

Bidragsyterens navn vises på dette resultatet som Guido Biele
  • Tilknyttet:
    Forfatter
    ved Psykologisk institutt ved Universitetet i Oslo
  • Tilknyttet:
    Forfatter
    ved Max-Planck-Institut für Bildungsforschung

Lea K. Krugel

  • Tilknyttet:
    Forfatter
    ved Charité - Universitätsmedizin Berlin
  • Tilknyttet:
    Forfatter
    ved Max-Planck-Institut für Bildungsforschung

Frank Marzinzik

  • Tilknyttet:
    Forfatter
    ved Charité - Universitätsmedizin Berlin

M. Wahl

Bidragsyterens navn vises på dette resultatet som Michael Wahl
  • Tilknyttet:
    Forfatter
    ved Charité - Universitätsmedizin Berlin
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