Cristin-resultat-ID: 615022
Sist endret: 2. juni 2017, 12:11
Vitenskapelig foredrag

Genetic variation in the hemagglutinin gene of infectious salmon anaemia virus

  • Siri Mjaaland
  • Finn Sverre Drabløs
  • Olav Hungnes
  • Ann Teig
  • Birgit Dannevig og
  • Espen Rimstad


Navn på arrangementet: The 5th Nordic Symposium on Fish Immunology
Sted: Sundvollen, Norway
Dato fra: 18. juni 2001
Dato til: 22. juni 2001

Om resultatet

Vitenskapelig foredrag
Publiseringsår: 2001


ForskDok-ID: r02006947




Beskrivelse Beskrivelse


Genetic variation in the hemagglutinin gene of infectious salmon anaemia virus


Infectious salmon anaemia virus (ISAV), an economically important pathogen for the salmon farming industry in the northern hemisphere, closely resembles orthomyxoviruses, which include the influenza viruses. The influenza viruses are characterized by their continuous change in genetic material driven by the hosts immune defence, and as a consequence, a great variation in the severity of the infection is seen. In ISAV infections, differences in the course of the disease and clinical signs have been observed, as well as in cell culture replication. These differences indicate variations both in the virulence and antigenic composition of the virus. Nucleotide and amino acid sequence alignments were performed on 33 ISA disease outbreaks picked from all along the Norwegian coast covering a ten year period. A polymorf region was detected, and depending on type of variation the disease outbreaks fell into eight separate groups. From some of the more diffuse disease outbreaks, where one had not been able to isolate virus, cloning of RT-PCR products from diseased fish homogenates resulted in detection of not just one, but two to three variable groups from the same outbreak. Comparisons between members of the groups with regard to development of cytopathogenic effect and virus titres in cell culture showed variation between the groups. Here we describe the ISAV hemagglutinin gene: both nucleotide / amino acid comparisons and the estimated 3D structure of this molecule.


Siri Mjaaland

  • Tilknyttet:
    ved Institutt for prekliniske fag og patologi ved Norges miljø- og biovitenskapelige universitet

Finn Sverre Drabløs

  • Tilknyttet:
    ved SINTEF AS

Olav Hungnes

  • Tilknyttet:
    ved Folkehelseinstituttet

Ann Teig

  • Tilknyttet:
    ved Norges miljø- og biovitenskapelige universitet
  • Tilknyttet:

Birgit Dannevig

  • Tilknyttet:
    ved Immunologi og virologi ved Veterinærinstituttet
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