Cristin-resultat-ID: 618133
Sist endret: 2. juni 2017 12:10
NVI-rapporteringsår: 2010
Resultat
Vitenskapelig artikkel
2010

Applying fractal analysis to heart rate time series of sheep experiencing pain

Bidragsytere:
  • Solveig Marie Stubsjøen
  • Jon Bohlin
  • Eystein Skjerve
  • Paul Steinar Valle og
  • Adroaldo José Zanella

Tidsskrift

Physiology and Behavior
ISSN 0031-9384
e-ISSN 1873-507X
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2010
Volum: 101
Hefte: 1
Sider: 74 - 80

Importkilder

Isi-ID: 000280118300010

Beskrivelse Beskrivelse

Tittel

Applying fractal analysis to heart rate time series of sheep experiencing pain

Sammendrag

The objective assessment of pain is difficult in animals and humans alike. Detrended fluctuation analysis (DFA) is a method which extracts "hidden" information from heart rate time series, and may offer a novel way of assessing the subjective experience associated with pain. The aim of this study was to investigate whether any fractal differences could be detected in heart rate time series of sheep due to the infliction of ischaemic pain. Heart rate variability (HRV) was recorded continuously in five ewes during treatment sequences of baseline, intervention and post-intervention for up to 60 min. Heart rate time series were subjected to a DFA, and the median of the scaling coefficients (alpha) was found to be alpha = 1.10 for the baseline sequences, 1.01 for the intervention sequences and 1.00 for the post-intervention sequences. The complexity in the regulation of heartbeats decreased between baseline and intervention (p similar to 0.03) and baseline and post-intervention (p similar to 0.01). indicating reperfusion pain and nociceptive sensitization in the post-intervention sequence. Random time series based on Gaussian white noise were generated, with similar mean and variance to the HRV sequences. No difference was found between these series (p similar to 0.28), pointing to a true difference in complexity in the original data. We found no difference in the scaling coefficient a between the different treatments, possibly due to the small sample size or a fear induced sympathetic arousal during test day 1 confounding the results. The decrease in the sealing coefficient alpha may be due to sympathetic activation and vagal withdrawal. DFA of heart rate time series may be a useful method to evaluate the progressive shift of cardiac regulation toward sympathetic activation and vagal withdrawal produced by pain or negative emotional responses such as fear. (C) 2010 Elsevier Inc. All rights reserved.

Bidragsytere

Solveig Marie Stubsjøen

  • Tilknyttet:
    Forfatter
    ved Animalia
  • Tilknyttet:
    Forfatter
    ved Institutt for produksjonsdyrmedisin ved Norges miljø- og biovitenskapelige universitet

Jon Bohlin

  • Tilknyttet:
    Forfatter
    ved Institutt for prekliniske fag og patologi ved Norges miljø- og biovitenskapelige universitet

Eystein Skjerve

  • Tilknyttet:
    Forfatter
    ved Institutt for prekliniske fag og patologi ved Norges miljø- og biovitenskapelige universitet

Paul Steinar Valle

  • Tilknyttet:
    Forfatter
    ved Institutt for produksjonsdyrmedisin ved Norges miljø- og biovitenskapelige universitet
  • Tilknyttet:
    Forfatter
    ved Avdeling for helse- og sosialfag ved Høgskolen i Molde - Vitenskapelig høgskole i logistikk

Adroaldo Jose Zanella

Bidragsyterens navn vises på dette resultatet som Adroaldo José Zanella
  • Tilknyttet:
    Forfatter
    ved Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet
  • Tilknyttet:
    Forfatter
    ved Institutt for produksjonsdyrmedisin ved Norges miljø- og biovitenskapelige universitet
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