Cristin-resultat-ID: 641244
Sist endret: 9. juli 2014 13:37
Resultat
Vitenskapelig foredrag
2009

Analysis of diffusion-weighted MRI using different sets of b-values in locally advanced breast cancer

Bidragsytere:
  • Therese Seierstad
  • Line Brennhaug Nilsen
  • Oliver Geier og
  • Anne Fangberget

Presentasjon

Navn på arrangementet: ESMRMB (European Society for Magnetic Resonance in Medicine and Biology)
Sted: Antalya, Tyrkia
Dato fra: 1. oktober 2009
Dato til: 3. oktober 2009

Om resultatet

Vitenskapelig foredrag
Publiseringsår: 2009

Importkilder

ForskDok-ID: r09019841

Beskrivelse Beskrivelse

Tittel

Analysis of diffusion-weighted MRI using different sets of b-values in locally advanced breast cancer

Sammendrag

Purpose/Introduction: The apparent diffusion coefficient (ADC) obtained from diffusion-weighted MRI (DW-MRI) has been shown to be a promising quantitative parameter for radiological assessment of breast tumours [1]. Depending on manufacturer, coil configuration, gradient- and field strength, ADC-values have shown variability up to 9% [2]. Micro-vessel perfusion within the tumour affects the diffusion signal at low b-values. There is currently no consensus on optimal b-value selection and a large variety of b-values have been used in different breast cancer studies. The aim of this study was to examine the effect of b-value selection on ADC-values obtained in breast carcinoma. Subjects and Methods: Twenty-nine patients with locally advanced breast cancer (LABC) were included in this study. DW-MRI was performed on a 1.5T MR scanner (ESPREE, Siemens Medical Solutions) using a fat-saturated DWI echo-planar imaging sequence and b-values of 0, 50, 100, 250 and 800 s/mm2. ADC-values of individual breast tumours were calculated using a mono-exponential fitting approach and different b-value combinations: All b-values (ADCAll), excluding b=0 s/mm2 (ADC50-100-250-800), excluding b=0 and 50 s/mm2 (ADC100-250-800), b=50 and b=100s/mm2 (ADC50-100), b=100 and b=250s/mm2 (ADC100-250) and b=0 s/mm2 together with a single b value of either 50 (ADC0-50), 100 (ADC0-100), 250 (ADC0-250) or 800 s/mm2 (ADC0-800). ADC-values calculated from different datasets of b-values were normalized to ADCAll for each patient individually. Correlation between ADCAll and the other calculated ADC-values were examined using Spearman's rho correlation. Results: Mean breast tumour ADCAll was 1.29±0.27x10-3 mm2/s. ADC-values for different combinations of b-values normalized to ADCAll are shown in Fig. 1. Breast tumour ADC-values calculated using only low b-values exhibit larger inter-patient variations compared to ADC-values including high b-values in the calculation. Mean differences in ADC-values obtained for different b-value combinations and corresponding correlation coefficients are shown in Table 1a and b, respectively Discussion/Conclusion: The large inter-patient variations in ADC-values found for lower b-values can be ascribed to micro-vessel perfusion heterogeneity. These differences were larger than the variations caused by different hardware configurations [2]. The prospective of obtaining information on tumour vasculature when using low b-values, may be of increased importance in the future when anti-angiogenetic treatments are included as part of treatment for women with LABC.

Bidragsytere

Therese Seierstad

  • Tilknyttet:
    Forfatter
    ved Oslo universitetssykehus HF
  • Tilknyttet:
    Forfatter
  • Tilknyttet:
    Forfatter
    ved Universitetet i Sørøst-Norge

Line Brennhaug Nilsen

  • Tilknyttet:
    Forfatter
    ved Oslo universitetssykehus HF

Oliver Geier

  • Tilknyttet:
    Forfatter
    ved Oslo universitetssykehus HF

Anne Fangberget

  • Tilknyttet:
    Forfatter
    ved Oslo universitetssykehus HF
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