Cristin-resultat-ID: 848931
Sist endret: 17. februar 2012 12:25
NVI-rapporteringsår: 2011
Resultat
Vitenskapelig artikkel
2011

Cerebral gene expression and neurobehavioural development after perinatal exposure to an environmentally relevant polybrominated diphenylether (BDE47)

Bidragsytere:
  • Marte Haave
  • Kristin Ingvaldsen Folven
  • Thomas Carroll
  • Chris Glover
  • Einar Heegaard
  • Trond Brattelid
  • mfl.

Tidsskrift

Cell Biology and Toxicology
ISSN 0742-2091
e-ISSN 1573-6822
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2011
Volum: 27
Hefte: 5
Sider: 343 - 361

Importkilder

Isi-ID: 000294476600004

Klassifisering

Vitenskapsdisipliner

Matematikk og naturvitenskap

Beskrivelse Beskrivelse

Tittel

Cerebral gene expression and neurobehavioural development after perinatal exposure to an environmentally relevant polybrominated diphenylether (BDE47)

Sammendrag

Nutrients in seafood are known to be beneficial for brain development. Effects of maternal exposure to 2,2′,4,4′ tetrabromo diphenylether (BDE47) was investigated, alongside the potential ameliorating impact of seafood nutrients, through assessment of neurobehaviour and gene expression in brain and liver. Developing mice were exposed during gestation and lactation via dams dosed through casein- or salmon-based feed, spiked with BDE47. Two concentrations were used: a low level (6 μg/kg feed) representing an environmentally realistic concentration and a high level (1,900 μg/kg feed) representing a BDE47 intake much higher than expected from frequents consumption of contaminated seafood. Experimental groups were similar with respect to reproductive success, growth and physical development. Minor, transient changes in neurobehavioural metrics were observed in groups given the highest dose of BDE47. No significant differences in behaviour or development were seen on postnatal day 18 among maternally exposed offspring. Cerebral gene expression investigated by microarray analyses and validated by RT-qPCR showed low fold changes for all genes, despite dose-dependent accumulation of BDE47 in brain tissue. The gene for glutamate ammonia ligase was upregulated compared to control in the casein-based high BDE47diet, suggesting potential impacts on downstream synaptic transmission. The study supported a previously observed regulation of Igfbp2 in brain with BDE47 exposure. Genes for hepatic metabolic enzymes were not influenced by BDE47. Potential neurotoxic effects and neurobehavioural aberrations after perinatal exposure to high levels of BDE47 were not readily observed in mice pups with the present experimental exposure regimes and methods of analysis.

Bidragsytere

Aktiv cristin-person

Marte Haave

  • Tilknyttet:
    Forfatter
    ved Havforskningsinstituttet
  • Tilknyttet:
    Forfatter
    ved Institutt for biovitenskap ved Universitetet i Bergen

Kristin Ingvaldsen Folven

  • Tilknyttet:
    Forfatter
    ved Havforskningsinstituttet

Thomas Carroll

  • Tilknyttet:
    Forfatter
    ved King's College London, University of London

Chris Glover

  • Tilknyttet:
    Forfatter
    ved Havforskningsinstituttet

Einar Heegaard

  • Tilknyttet:
    Forfatter
    ved Divisjon for skog og utmark ved Norsk institutt for bioøkonomi
1 - 5 av 8 | Neste | Siste »