Cristin-resultat-ID: 942313
Sist endret: 25. oktober 2016 14:33
NVI-rapporteringsår: 2012
Resultat
Vitenskapelig artikkel
2012

Early combination of material characteristics and toxicology is useful in the design of low toxicity carbon nanofiber

Bidragsytere:
  • Ellen K Jensen
  • Sten Yngve Larsen
  • Unni Cecilie Nygaard
  • Calin Daniel Marioara og
  • Tore Syversen

Tidsskrift

Materials
ISSN 1996-1944
e-ISSN 1996-1944
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2012
Volum: 5
Hefte: 9
Sider: 1560 - 1580
Open Access

Importkilder

Isi-ID: 000309271900003

Klassifisering

Vitenskapsdisipliner

Toksikologi

Emneord

Toksisitetstester • Nanofibre • Karbonater • Materialteknologi

Beskrivelse Beskrivelse

Tittel

Early combination of material characteristics and toxicology is useful in the design of low toxicity carbon nanofiber

Sammendrag

This paper describes an approach for the early combination of material characterization and toxicology testing in order to design carbon nanofiber (CNF) with low toxicity. The aim was to investigate how the adjustment of production parameters and purification procedures can result in a CNF product with low toxicity. Different CNF batches from a pilot plant were characterized with respect to physical properties (chemical composition, specific surface area, morphology, surface chemistry) as well as toxicity by in vitro and in vivo tests. A description of a test battery for both material characterization and toxicity is given. The results illustrate how the adjustment of production parameters and purification, thermal treatment in particular, influence the material characterization as well as the outcome of the toxic tests. The combination of the tests early during product development is a useful and efficient approach when aiming at designing CNF with low toxicity. Early quality and safety characterization, preferably in an iterative process, is expected to be efficient and promising for this purpose. The toxicity tests applied are preliminary tests of low cost and rapid execution. For further studies, effects such as lung inflammation, fibrosis and respiratory cancer are recommended for the more in-depth studies of the mature CNF product.

Bidragsytere

Ellen K Jensen

  • Tilknyttet:
    Forfatter
    ved Equinor

Sten Yngve Larsen

  • Tilknyttet:
    Forfatter
    ved Elkem AS

Unni Cecilie Nygaard

  • Tilknyttet:
    Forfatter
    ved Avdeling for miljø og helse ved Folkehelseinstituttet

Calin Daniel Marioara

  • Tilknyttet:
    Forfatter
    ved Materialer og nanoteknologi ved SINTEF AS

Tore Syversen

  • Tilknyttet:
    Forfatter
    ved Institutt for nevromedisin og bevegelsesvitenskap ved Norges teknisk-naturvitenskapelige universitet
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