Cristin-resultat-ID: 974153
Sist endret: 25. februar 2013 09:58
NVI-rapporteringsår: 2012
Resultat
Vitenskapelig artikkel
2012

Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients

Bidragsytere:
  • Siv Kjølsrud Bøhn
  • Kjell Magne Russnes
  • Amrit Kaur Sakhi
  • Magne Thoresen
  • Marit Holden
  • Jan Øivind Moskaug
  • mfl.

Tidsskrift

BMC Cancer
ISSN 1471-2407
e-ISSN 1471-2407
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2012
Publisert online: 2012
Volum: 12
Artikkelnummer: 426
Open Access

Importkilder

Isi-ID: 000312100800003

Beskrivelse Beskrivelse

Tittel

Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients

Sammendrag

Background We previously observed that a radiotherapy-induced biochemical response in plasma was associated with favourable outcome in head and neck squamous carcinoma cancer (HNSCC) patients. The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy. Methods Out of 87 patients (histologically verified), 10 biochemical ‘responders’ having a high relative increase in plasma oxidative damage and a concomitant decrease in plasma antioxidants during radiotherapy and 10 ‘poor-responders’ were selected for gene-expression analysis and compared using gene set enrichment analysis. Results There was a significant induction of stress-relevant gene-sets in the responders following radiotherapy compared to the poor-responders. The relevance of the involvement of similar stress associated gene expression for HNSCC cancer and radioresistance was verified using two publicly available data sets of 42 HNSCC cases and 14 controls (GEO GSE6791), and radiation resistant and radiation sensitive HNSCC xenografts (E-GEOD-9716). Conclusions Radiotherapy induces a systemic stress response, as revealed by induction of stress relevant gene expression in blood cells, which is associated to favourable outcome in a cohort of 87 HNSCC patients. Whether these changes in gene expression reflects a systemic effect or are biomarkers of the tumour micro-environmental status needs further study.

Bidragsytere

Siv Kjølsrud Bøhn

  • Tilknyttet:
    Forfatter
    ved Ernæringsvitenskap: Mat og oksidativt stress ved Universitetet i Oslo

Kjell Magne Russnes

  • Tilknyttet:
    Forfatter
    ved Onkologisk fagseksjon 2 ved Oslo universitetssykehus HF

Amrit Kaur Sakhi

  • Tilknyttet:
    Forfatter
    ved Avdeling for ernæringsvitenskap ved Universitetet i Oslo

Magne Thoresen

  • Tilknyttet:
    Forfatter
    ved Biostatistikk: Biostatistiske metoder og anvendelser ved Universitetet i Oslo

Marit Holden

  • Tilknyttet:
    Forfatter
    ved Statistisk analyse, maskinlæring og bildeanalyse SAMBA ved Norsk Regnesentral
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