Chicken fileting gives rise to a large amount of rest raw material with high protein quality that can be used to generate chicken protein hydrolysates (CPH) through specific enzymatic processes. Pre-clinical studies in mice have demonstrated potent plasma cytokine lowering abilities and atherosclerosis-prevention by CPH-diets, as well as beneficial effects on plasma cholesterol level, cytokines and lipid metabolism, including mitochondrial function. In addition, an isolated peptide fraction from chicken inhibits the dipeptyl peptidase IV, and thus has the potential to restore glucose homeostasis in type 2 diabetics. In this study, a CPH supplement will be administered to healthy subjects with high waist circumference and a moderate to high BMI, and the potential effects on body weight, abdominal obesity, body composition, plasma parameters of metabolic health including lipids, inflammatory parameters, redox state and microbiota biomarkers will be investigated.
