Cristin-prosjekt-ID: 360602
Sist endret: 11. desember 2013 13:09

Cristin-prosjekt-ID: 360602
Sist endret: 11. desember 2013 13:09
Prosjekt

Pandemic influenza A (H1N1) 2009 virus in pigs - infection dynamics, genetic

prosjektleder

Hilde Sindre
ved Forskningsgruppe fiskehelse ved Veterinærinstituttet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Forskningsgruppe fiskehelse ved Veterinærinstituttet

Klassifisering

Emneord

Dyr

Tidsramme

Avsluttet
Start: 1. januar 2011 Slutt: 21. desember 2013

Beskrivelse Beskrivelse

Tittel

Pandemic influenza A (H1N1) 2009 virus in pigs - infection dynamics, genetic

Vitenskapelig sammendrag

A new strain of influenza A H1N1 virus, pandemic H1N1 2009 virus(pH1N1-09v), was detected in the spring of 2009. In a few months this novel virus had spread worldwide to humans and animals and attained pandemic status in June 2009. The rapid spread was caused by increasing globalization due to extensive traveling across country borders. It is unclear whether pigs serve as reservoirs for pH1N1-09v and/or as 'mixing vessels' between pH1N1-09v and other subtypes of influenza to produce new strains with zoonotic potential. In this project we aim to explore the disease dynamics of pH1N1-09v in a pig population that until the outbreak of pH1N1-09v was naïve to influenza. If pH1N1-09 becomes established in the Norwegian pig population it may adapt to pigs by mutations and/or reassortment. This can result in new virus variants that may transmit back to humans. Virus evolution in swine contra humans will therefore be studied. The pH1N1-09v that affected the Norwegian swine population induced significant lung pathology with mild to moderate clinical signs. A betterknowledge of the pathogenesis of the lesions induced by this virus will enables us in the future to pick up possible changes in virus pathogenicity. Therefore, the pathogenesis in pigs naturally infected with pH1N1-09v andpreviously not exposed to swine influenza will be described. In addition,virus-host interactions, in particular cellular and humoral immune responses in naïve pigs will be studied. The results from this project will therefore provide unique knowledge on the infection dynamics of pH1N1-09v in a naive pig population, and will give early warning to the human health authorities on the development of potentially new zoonotic influenza strainsin the pig population. It will also give valuable information to the food safety authorities and the pig industry regarding disease control measures to minimize economic consequences, improve welfare, and ensure safe andbetter quality pork products.

prosjektdeltakere

prosjektleder

Hilde Sindre

  • Tilknyttet:
    Prosjektleder
    ved Forskningsgruppe fiskehelse ved Veterinærinstituttet

Britt Gjerset

  • Tilknyttet:
    Prosjektdeltaker
    ved Immunologi og virologi ved Veterinærinstituttet

Bjørn Lium

  • Tilknyttet:
    Prosjektdeltaker
    ved Husdyr, vilt og velferd ved Veterinærinstituttet

Anne Storset

  • Tilknyttet:
    Prosjektdeltaker
    ved Institutt for prekliniske fag og patologi ved Norges miljø- og biovitenskapelige universitet

Mette Valheim

  • Tilknyttet:
    Prosjektdeltaker
    ved Patologi Oslo og Tromsø ved Veterinærinstituttet
1 - 5 av 14 | Neste | Siste »

Resultater Resultater

Pathological Findings and Distribution of Pandemic Influenza A (H1N1) 2009 Virus in Lungs from Naturally Infected Fattening Pigs in Norway.

Valheim, Mette; Gamlem, Hans Norvald; Gjerset, Britt; Germundsson, Anna; Lium, Bjørn. 2011, Influenza Research and Treatment. VETINSTVitenskapelig artikkel

Experiences after twenty months with pandemic influenza a (H1N1) 2009 infection in the naive norwegian pig population.

Gjerset, Britt; Er, Chiek; Løtvedt, Siri; Jørgensen, Anne; Hungnes, Olav; Lium, Bjørn; Germundsson, Anna. 2011, Influenza Research and Treatment. VETINST, FHI, ANIMALIA, MATTILSYNVitenskapelig artikkel

Clinical impact of infection with pandemic influenza (H1N1) 2009 virus in naïve nucleus and multiplier pig herds in Norway.

Grøntvedt, Carl Andreas; Er Jwee, Chiek; Gjerset, Britt; Germundsson, Anna; Framstad, Tore; Brun, Edgar; Jørgensen, Anne; Lium, Bjørn. 2011, Influenza Research and Treatment. VETINST, NMBU, ANIMALIAVitenskapelig artikkel
1 - 3 av 3