Cristin-prosjekt-ID: 592631
Sist endret: 26. november 2020 11:23

Cristin-prosjekt-ID: 592631
Sist endret: 26. november 2020 11:23
Prosjekt

AMR-Diag: A Novel Diagnostic Tool for Sequence Based Prediction of Antimicrobial Resistance

prosjektleder

Rafi Ahmad
ved Institutt for bioteknologi ved Høgskolen i Innlandet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Høgskolen i Innlandet

Finansiering

  • TotalbudsjettNOK 5.300.000
  • Norges forskningsråd
    Prosjektkode: 273609

Klassifisering

Vitenskapsdisipliner

Genetikk og genomikk • Bioinformatikk • Medisinsk mikrobiologi • Molekylærbiologi

Kategorier

Prosjektkategori

  • Anvendt forskning

Tidsramme

Aktivt
Start: 1. april 2018 Slutt: 31. mars 2021

Beskrivelse Beskrivelse

Tittel

AMR-Diag: A Novel Diagnostic Tool for Sequence Based Prediction of Antimicrobial Resistance

Populærvitenskapelig sammendrag

The emergence and spread of antibiotic resistant (ABR) bacteria is defined as a global health problem by the WHO. The situation is at its gravest in low- and middle-income countries (including India), where antibiotic consumption is high and largely unregulated. In Europe, an estimated 25,000 patients die annually from ABR bacteria. Treating resistant infections results in extra costs and productivity losses, for e.g., in USA an estimated $21 - $34 billion and in Europe 1.5 billion Euro annually. Despite Norway having amongst the lowest use of antibiotics in all of Europe, there has been a recent increase in reported cases for various ABR infections.

Lack of rapid point-of-care diagnostic tests is central to this problem, as studies show that up to 70% of antibiotics are prescribed incorrectly. This is due to physicians not being able to diagnose patients accurately in real-time, leading to prescription of antibiotics for viral infections, or prescription of broad-spectrum antibiotics that should ideally be kept in reserve. This diagnostic hitch is due to the current standard methodology employed in identifying bacterial infections, where the wait time for results is typically 2 - 4 days.

Taking advantage of the advances in whole genome sequencing, bioinformatics, proteomics and machine learning methods we plan to develop a decision-making tool AMR-Diag, for the detection of bacterial infection, including its resistance profile. We will sequence a number of human clinical samples to cover Extended Spectrum Beta-Lactamases (ESBLs) in Gram negative bacteria with focus on Escherichia coli, Klebsiella, and Acinetobacter. The developed tool will be evaluated on clinical samples from hospitals in Indian and Norway. AMR-Diag tool will be designed for use by doctors and other health care professionals, providing information needed in order to choose the best treatment. Thereby, resulting in more prudent and appropriate use of antibiotics.

prosjektdeltakere

prosjektleder

Rafi Ahmad

  • Tilknyttet:
    Prosjektleder
    ved Institutt for bioteknologi ved Høgskolen i Innlandet

Mohammed Umaer Naseer

  • Tilknyttet:
    Prosjektdeltaker
    ved Folkehelseinstituttet

Arne Michael Taxt

  • Tilknyttet:
    Prosjektdeltaker
    ved Inst. eksperimentell med. forsk, Ullevål ved Oslo universitetssykehus HF

Ørjan Samuelsen

  • Tilknyttet:
    Prosjektdeltaker
    ved Medisinsk klinikk ved Universitetssykehuset Nord-Norge HF
  • Tilknyttet:
    Prosjektdeltaker
    ved Forskningsgruppe i mikrobiologi ved UiT Norges arktiske universitet

Ekaterina Avershina

  • Tilknyttet:
    Prosjektdeltaker
    ved Høgskolen i Innlandet
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Resultater Resultater

Rapid identification of pathogens, antibiotic resistance encoding genes and plasmids in blood cultures by nanopore sequencing. .

Taxt, Arne Michael. 2019, National Consortium for Microbial Genomics Meeting. UIBVitenskapelig foredrag

Rapid resistance detection from blood cultures.

Taxt, Arne Michael. 2020, TTA Fall meeting 2020. UIBVitenskapelig foredrag

Resistome Identification of Whole Genome Sequencing Data of Norwegian Isolates.

Kauser, Ambreen. 2020, Høgskolen i Hedmark. HINNMastergradsoppgave
1 - 5 av 31 | Neste | Siste »