Cristin-resultat-ID: 1121297
Sist endret: 5. november 2014 11:22
NVI-rapporteringsår: 2014
Resultat
Vitenskapelig artikkel
2014

Active and passive cigarette smoking and breast cancer risk: Results from the EPIC cohort

Bidragsytere:
  • Laure Dossus
  • Marie-Christine Boutron-Ruault
  • Rudolf Kaaks
  • Inger Torhild Gram
  • Alice Vilier
  • Beatrice Fervers
  • mfl.

Tidsskrift

International Journal of Cancer
ISSN 0020-7136
e-ISSN 1097-0215
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2014
Publisert online: 2014
Trykket: 2014
Volum: 134
Hefte: 8
Sider: 1871 - 1888

Importkilder

Scopus-ID: 2-s2.0-84893727738

Beskrivelse Beskrivelse

Tittel

Active and passive cigarette smoking and breast cancer risk: Results from the EPIC cohort

Sammendrag

Recent cohort studies suggest that increased breast cancer risks were associated with longer smoking duration, higher pack-years and a dose-response relationship with increasing pack-years of smoking between menarche and first full-term pregnancy (FFTP). Studies with comprehensive quantitative life-time measures of passive smoking suggest an association between passive smoking dose and breast cancer risk. We conducted a study within the European Prospective Investigation into Cancer and Nutrition to examine the association between passive and active smoking and risk of invasive breast cancer and possible effect modification by known breast cancer risk factors. Among the 322,988 women eligible for the study, 9,822 developed breast cancer (183,608 women with passive smoking information including 6,264 cases). When compared to women who never smoked and were not being exposed to passive smoking at home or work at the time of study registration, current, former and currently exposed passive smokers were at increased risk of breast cancer (hazard ratios (HR) [95% confidence interval (CI)] 1.16 [1.05–1.28], 1.14 [1.04–1.25] and 1.10 [1.01–1.20], respectively). Analyses exploring associations in different periods of life showed the most important increase in risk with pack-years from menarche to FFTP (1.73 [1.29–2.32] for every increase of 20 pack-years) while pack-years smoked after menopause were associated with a significant decrease in breast cancer risk (HR = 0.53, 95% CI: 0.34–0.82 for every increase of 20 pack-years). Our results provide an important replication, in the largest cohort to date, that smoking (passively or actively) increases breast cancer risk and that smoking between menarche and FFTP is particularly deleterious.

Bidragsytere

Laure Dossus

  • Tilknyttet:
    Forfatter
    ved Université Paris-Saclay
  • Tilknyttet:
    Forfatter
    ved Institut Gustave-Roussy

Marie-Christine Boutron-Ruault

  • Tilknyttet:
    Forfatter
    ved Université Paris-Saclay
  • Tilknyttet:
    Forfatter
    ved Institut Gustave-Roussy

Rudolf Kaaks

  • Tilknyttet:
    Forfatter
    ved Deutsches Krebsforschungszentrum
Aktiv cristin-person

Inger Torhild Gram

  • Tilknyttet:
    Forfatter
    ved Systems epidemiology, forskningsgruppe ved UiT Norges arktiske universitet
  • Tilknyttet:
    Forfatter
    ved Nasjonalt senter for e-helseforskning ved Universitetssykehuset Nord-Norge HF

Alice Vilier

  • Tilknyttet:
    Forfatter
    ved Université Paris-Saclay
  • Tilknyttet:
    Forfatter
    ved Institut Gustave-Roussy
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