Oxidative stress and myocardial damage during elective percutaneous coronary interventions and coronary angiography. A comparison of blood-borne isoprostane and troponin release

Oxidative stress and myocardial damage during elective percutaneous coronary interventions and coronary angiography. A comparison of blood-borne isoprostane and troponin release. Kirsti Berg1, Rune Wiseth1, Samar Basu2, Sissel Skarra1, Heidi Brurok1 and Per Jynge1 1 Department of Circulation and Medical Imaging (ISB), Norwegian University of Science and Technology (NTNU), Norway 2 Sections of Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, Sweden. Background Percutaneous coronary intervention (PCI) is a rapidly expanding treatment for both chronic and acute stages of coronary artery disease. PCI has become a main-line therapy and is generally recognised as a versatile and safe technique. Repeated balloon inflations make PCI a clinical model of myocardial ischemia-reperfusion and following PCI elevation in markers of myocardial damage occurs frequently. Both oxidative injury and inflammatory processes are supposed to play an important factor in reperfusion injury. However the presence and potential role of oxidative stress during PCI remain controversial. (Bilde, PCI ) Aims The aims of the present study were to examine if minor ischemic episodes as may occur during elective percutaneous coronary intervention (PCI) induce oxidative stress and, eventually, if oxygen stress correlates with myocardial injury. Methods 38 and 9 patients underwent PCI and diagnostic coronary angiography, respectively. Peripheral blood was sampled at different timepoints for plasma analyses of: 8-iso-PGF2 (oxidative stress); 15-keto-DH-PGF2 (inflammation); Troponin-T (myocardial injury); vitamin A and vitamin E; and, total antioxidants status (TAS).