Sammendrag
A library of small aminobenzamide derivatives was synthesised to explore a cationic amphipathic motif
found in marine natural antimicrobials. The most potent compound E23 displayed minimal inhibitory
concentrations (MICs) of 0.5–2 lg/ml against several Gram-positive bacterial strains, including methicillin
resistant Staphylococcus epidermidis (MRSE). E23 was also potent against 275 clinical isolates including
Staphylococcus aureus, Enterococcus spp., Escherichia coli, Pseudomonas aeruginosa, and Klebsiella
pneumoniae, as well as methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE),
and ESBL–CARBA producing multi-resistant Gram-negative bacteria. The study demonstrates how structural
motifs found in marine natural antimicrobials can be a valuable source for making novel antimicrobial
lead-compounds.
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