Cristin-resultat-ID: 1410014
Sist endret: 8. februar 2018 10:41
NVI-rapporteringsår: 2016
Resultat
Vitenskapelig artikkel
2016

Prevalence and epidemiology of meningococcal carriage in Southern Ethiopia prior to implementation of MenAfriVac, a conjugate vaccine

Bidragsytere:
  • Guro Kristine Bårnes
  • Paul Arne Kristiansen
  • Demissew Beyene
  • Bereket Workalemahu
  • Paulos Fissiha
  • Behailu Merdekios
  • mfl.

Tidsskrift

BMC Infectious Diseases
ISSN 1471-2334
e-ISSN 1471-2334
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2016
Volum: 16
Hefte: 1
Artikkelnummer: 639
Open Access

Importkilder

Scopus-ID: 2-s2.0-84994493278

Beskrivelse Beskrivelse

Tittel

Prevalence and epidemiology of meningococcal carriage in Southern Ethiopia prior to implementation of MenAfriVac, a conjugate vaccine

Sammendrag

Background Neisseria meningitidis colonizes humans and transmits mainly by asymptomatic carriage. We sought to determine the prevalence and epidemiology of meningococcal carriage in Ethiopia prior to the introduction of MenAfriVac, a serogroup A meningococcal conjugate vaccine. Methods A cross-sectional meningococcal carriage study was conducted in Arba Minch, southern Ethiopia. A total of 7479 oropharyngeal samples were collected from 1 to 29 year old volunteers, between March and October, 2014. The swabs were cultured for N. meningitidis and Neisseria lactamica in Ethiopia. N. meningitidis isolates were confirmed and characterized by their serogroup, sequence type (ST) and PorA:FetA profile in Norway. Results Overall carriage prevalence was 6.6 %. There was no significant difference in overall carriage between male (6.7 %) and female (6.4 %) participants. Highest carriage prevalence (10.9 %) for females was found in the 15–19 years of age, while prevalence among males was highest (11.3 %) in the 20–24 age group. Non-groupable isolates dominated (76.4 %), followed by serogroups X (14.0 %) and W (5.9 %) isolates. No serogroup A was found. Most non-groupable isolates were ST-192. Serogroup W isolates were assigned to the ST-11 clonal complex, and serogroup X isolates to the ST-181 and ST-41/44 clonal complexes. Overall carriage prevalence of N. lactamica was 28.1 %. Carriage of N. meningitidis and N. lactamica varied depending on age and geographic area, but there was no association between carriage of the two species. Conclusions Epidemic strains of serogroups W and X were circulating in this area of Ethiopia. As no serogroup A was found among the carriage isolates the immediate impact of mass-vaccination with MenAfriVac on transmission of N. meningitidis in this population is expected to be marginal.

Bidragsytere

Guro Kristine Bårnes

  • Tilknyttet:
    Forfatter
    ved Folkehelseinstituttet
  • Tilknyttet:
    Forfatter
    ved Avdeling for molekylærmedisin ved Universitetet i Oslo

Paul Arne Kristiansen

  • Tilknyttet:
    Forfatter
    ved Avdeling for bakteriologi ved Folkehelseinstituttet

D Beyene

Bidragsyterens navn vises på dette resultatet som Demissew Beyene
  • Tilknyttet:
    Forfatter
    ved AHRI Armauer Hansen Research Institute

Bereket Workalemahu

  • Tilknyttet:
    Forfatter
    ved Arba Minch University

P. Fissiha

Bidragsyterens navn vises på dette resultatet som Paulos Fissiha
  • Tilknyttet:
    Forfatter
    ved Arba Minch University
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