Cristin-resultat-ID: 1596514
Sist endret: 17. desember 2018 16:35
NVI-rapporteringsår: 2018
Resultat
Vitenskapelig artikkel
2018

Early life stress induces long-term changes in limbic areas of a teleost fish: The role of catecholamine systems in stress coping

Bidragsytere:
  • Marco A Vindas
  • Stefanos Fokos
  • Michail Pavlidis
  • Erik Höglund
  • Sylvia Dionysopoulou
  • Lars OE Ebbesson
  • mfl.

Tidsskrift

Scientific Reports
ISSN 2045-2322
e-ISSN 2045-2322
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2018
Volum: 8
Artikkelnummer: 5638
Open Access

Importkilder

Scopus-ID: 2-s2.0-85044994347

Finansiering

  • EC/FP7
    Prosjektkode: 265957

Beskrivelse Beskrivelse

Tittel

Early life stress induces long-term changes in limbic areas of a teleost fish: The role of catecholamine systems in stress coping

Sammendrag

Early life stress (ELS) shapes the way individuals cope with future situations. Animals use cognitive flexibility to cope with their ever-changing environment and this is mainly processed in forebrain areas. We investigated the performance of juvenile gilthead seabream, previously subjected to an ELS regime. ELS fish showed overall higher brain catecholaminergic (CA) signalling and lower brain derived neurotrophic factor (bdnf) and higher cfos expression in region-specific areas. All fish showed a normal cortisol and serotonergic response to acute stress. Brain dopaminergic activity and the expression of the α2Α adrenergic receptor were overall higher in the fish homologue to the lateral septum (Vv), suggesting that the Vv is important in CA system regulation. Interestingly, ELS prevented post-acute stress downregulation of the α2Α receptor in the amygdala homologue (Dm3). There was a lack of post-stress response in the β2 adrenergic receptor expression and a downregulation in bdnf in the Dm3 of ELS fish, which together indicate an allostatic overload in their stress coping ability. ELS fish showed higher neuronal activity (cfos) post-acute stress in the hippocampus homologue (Dlv) and the Dm3. Our results show clear long-term effects on limbic systems of seabream that may compromise their future coping ability to environmental challenges.

Bidragsytere

Marco Vindas

Bidragsyterens navn vises på dette resultatet som Marco A Vindas
  • Tilknyttet:
    Forfatter
    ved NORCE Miljø ved NORCE Norwegian Research Centre AS
  • Tilknyttet:
    Forfatter
    ved Göteborgs universitet

Stefanos Fokos

  • Tilknyttet:
    Forfatter
    ved Panepistimion Patron

Michael Pavlidis

Bidragsyterens navn vises på dette resultatet som Michail Pavlidis
  • Tilknyttet:
    Forfatter
    ved University of Crete

Erik Höglund

  • Tilknyttet:
    Forfatter
    ved Akvakultur ved Norsk institutt for vannforskning
  • Tilknyttet:
    Forfatter
    ved Danmarks Tekniske Universitet

Sylvia Dionysopoulou

  • Tilknyttet:
    Forfatter
    ved Panepistimion Patron
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