Cristin-resultat-ID: 1696151
Sist endret: 13. august 2019, 16:33
NVI-rapporteringsår: 2019
Resultat
Vitenskapelig artikkel
2019

Osteochondrosis in the distal femoral physis of pigs starts with vascular failure

Bidragsytere:
  • Kristin Olstad
  • Bjørn Håkon Wormstrand
  • Jørgen Kongsro og
  • Eli Grindflek

Tidsskrift

Veterinary pathology
ISSN 0300-9858
e-ISSN 1544-2217
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2019
Publisert online: 2019
Trykket: 2019
Volum: 56
Hefte: 5
Sider: 732 - 742

Importkilder

Scopus-ID: 2-s2.0-85065514153

Beskrivelse Beskrivelse

Tittel

Osteochondrosis in the distal femoral physis of pigs starts with vascular failure

Sammendrag

Articular osteochondrosis (OC) arises due to vascular failure and ischemic chondronecrosis. The aim of the study was to describe the histological and computed tomographic (CT) characteristics of changes in the distal femoral physis of pigs, to determine if they represented OC lesions and if the pathogenesis was the same as for articular OC. The material included 19 male Landrace pigs bred for predisposition to OC. One or 2 pigs were euthanized and CT-scanned at 2-week intervals from 82 to 180 days of age. Material from 10 pigs was available for histological validation. The CT scans revealed 31 lesions confirmed in 3 planes and 1 additional macroscopically visible lesion confirmed in 2 CT planes. Twelve of the lesions were histologically validated. All lesions were compatible with OC. Cartilage canal and eosinophilic streak morphological changes corresponded to failure of end arteries coursing from the epiphysis, toward the metaphysis. The location of lesions was compatible with failure at the point of vessel incorporation into bone. Vascular failure was associated with retention of viable hypertrophic chondrocytes and delayed ossification but not cartilage necrosis. Lesion width ranged from 1.1% to 45.6% of the physis. Several lesions were expected to resolve due to small size and evidence of CT-identifiable, reparative ossification. Angular limb deformity was not detected in any pig. The pathogenesis of physeal OC started with vascular failure that was morphologically identical to articular OC. The heritable predisposition may therefore be the same. The association between lesions and limb deformity should be studied further in older pigs in future.

Bidragsytere

Kristin Olstad

  • Tilknyttet:
    Forfatter
    ved Institutt for sports- og familiedyrmedisin ved Norges miljø- og biovitenskapelige universitet

Bjørn Håkon Wormstrand

  • Tilknyttet:
    Forfatter
    ved Institutt for sports- og familiedyrmedisin ved Norges miljø- og biovitenskapelige universitet
Aktiv cristin-person

Jørgen Kongsro

  • Tilknyttet:
    Forfatter
    ved Norsvin

Eli Grindflek

  • Tilknyttet:
    Forfatter
    ved Norsvin
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