Cristin-resultat-ID: 1877269
Sist endret: 22. november 2021, 12:10
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening

Bidragsytere:
  • Yvonne Kohl
  • Margit Biehl
  • Sarah Spring
  • Michelle Hesler
  • Vladimir Ogourtsov
  • Miomir Todorovic
  • mfl.

Tidsskrift

Small
ISSN 1613-6810
e-ISSN 1613-6829
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Publisert online: 2021
Volum: 17
Artikkelnummer: 2006012
Open Access

Importkilder

Scopus-ID: 2-s2.0-85099395202

Beskrivelse Beskrivelse

Tittel

Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening

Sammendrag

Microfluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses for rapid and animal‐free risk assessment of new chemicals and drugs. Microfluidic cell‐based devices allow high‐throughput screening and flexible automation while lowering costs and reagent consumption due to their miniaturization. There is a growing need for faster and animal‐free approaches for drug development and safety assessment of chemicals (Registration, Evaluation, Authorisation and Restriction of Chemical Substances, REACH). The work presented describes a microfluidic platform for in vivo‐like in vitro cell cultivation. It is equipped with a wafer‐based silicon chip including integrated electrodes and a microcavity. A proof‐of‐concept using different relevant cell models shows its suitability for label‐free assessment of cytotoxic effects. A miniaturized microscope within each module monitors cell morphology and proliferation. Electrodes integrated in the microfluidic channels allow the noninvasive monitoring of barrier integrity followed by a label‐free assessment of cytotoxic effects. Each microfluidic cell cultivation module can be operated individually or be interconnected in a flexible way. The interconnection of the different modules aims at simulation of the whole‐body exposure and response and can contribute to the replacement of animal testing in risk assessment studies in compliance with the 3Rs to replace, reduce, and refine animal experiments.

Bidragsytere

Yvonne Kohl

  • Tilknyttet:
    Forfatter
    ved Fraunhofer-Institut für Biomedizinische Technik IBMT

Margit Biehl

  • Tilknyttet:
    Forfatter
    ved Fraunhofer-Institut für Biomedizinische Technik IBMT

Sarah Spring

  • Tilknyttet:
    Forfatter
    ved Fraunhofer-Institut für Biomedizinische Technik IBMT

Michelle Hesler

  • Tilknyttet:
    Forfatter
    ved Fraunhofer-Institut für Biomedizinische Technik IBMT

Vladimir Ogourtsov

  • Tilknyttet:
    Forfatter
    ved University College Cork
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