Cristin-resultat-ID: 1901610
Sist endret: 3. mai 2021 15:18
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis

Bidragsytere:
  • Ellen Færgestad Mosleth
  • Christian Alexander Vedeler
  • Kristian Hovde Liland
  • Anette McLeod
  • Gerd Haga Bringeland
  • Liesbeth Kroondijk
  • mfl.

Tidsskrift

Scientific Reports
ISSN 2045-2322
e-ISSN 2045-2322
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Volum: 11
Artikkelnummer: 4087
Open Access

Importkilder

Scopus-ID: 2-s2.0-85101280531

Beskrivelse Beskrivelse

Tittel

Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis

Sammendrag

Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease heterogeneity. We previously reported explorative multivariate analysis by hierarchical clustering of proteomics data of MS patients and controls, which resulted in two groups of individuals. Grouping reflected increased levels of intrathecal inflammatory response proteins and decreased levels of proteins involved in neural development in one group relative to the other group. MS patients and controls were present in both groups. Here we reanalysed these data and we also reanalysed data from an independent cohort of patients diagnosed with clinically isolated syndrome (CIS), who have symptoms of MS without evidence of dissemination in space and/or time. Some, but not all, CIS patients had intrathecal inflammation. The analyses reported here identified a common protein signature of MS/CIS that was not linked to elevated intrathecal inflammation. The signature included low levels of complement proteins, semaphorin-7A, reelin, neural cell adhesion molecules, inter-alpha-trypsin inhibitor heavy chain H2, transforming growth factor beta 1, follistatin-related protein 1, malate dehydrogenase 1 cytoplasmic, plasma retinol-binding protein, biotinidase, and transferrin, all known to play roles in neural development. Low levels of these proteins suggest that MS/CIS patients suffer from abnormally low oxidative capacity that results in disrupted neural development from an early stage of the disease.

Bidragsytere

Ellen Færgestad Mosleth

  • Tilknyttet:
    Forfatter
    ved Storbritannia og Nord-Irland
  • Tilknyttet:
    Forfatter
    ved Råvare og prosess ved NOFIMA

Christian Alexander Vedeler

  • Tilknyttet:
    Forfatter
    ved Nevroklinikken ved Helse Bergen HF - Haukeland universitetssykehus
  • Tilknyttet:
    Forfatter
    ved Klinisk institutt 1 ved Universitetet i Bergen

Kristian Hovde Liland

  • Tilknyttet:
    Forfatter
    ved Råvare og prosess ved NOFIMA
  • Tilknyttet:
    Forfatter
    ved Seksjon for datavitenskap ved Norges miljø- og biovitenskapelige universitet

Anette McLeod

  • Tilknyttet:
    Forfatter
    ved Råvare og prosess ved NOFIMA
  • Tilknyttet:
    Forfatter
    ved Senter for laboratoriemedisin ved Sykehuset Østfold HF

Gerd Haga Bringeland

  • Tilknyttet:
    Forfatter
    ved Klinisk institutt 1 ved Universitetet i Bergen
  • Tilknyttet:
    Forfatter
    ved Nevroklinikken ved Helse Bergen HF - Haukeland universitetssykehus
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