Cristin-resultat-ID: 1901932
Sist endret: 14. februar 2022, 12:39
NVI-rapporteringsår: 2021
Resultat
Vitenskapelig artikkel
2021

A new synthetic protectin D1 analog 3-oxa-PD1n-3 DPA reduces neuropathic pain and chronic itch in mice

Bidragsytere:
  • Jannicke Irina Nesman
  • Ouyang Chen
  • Xin Luo
  • Ru-Rong Ji
  • Charles N. Serhan og
  • Trond Vidar Hansen

Tidsskrift

Organic and biomolecular chemistry
ISSN 1477-0520
e-ISSN 1477-0539
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2021
Publisert online: 2021
Trykket: 2021
Volum: 19
Sider: 2744 - 2752

Importkilder

Scopus-ID: 2-s2.0-85103501343

Beskrivelse Beskrivelse

Tittel

A new synthetic protectin D1 analog 3-oxa-PD1n-3 DPA reduces neuropathic pain and chronic itch in mice

Sammendrag

The resolution of inflammation is a biosynthetically active process controlled by the interplay between oxygenated polyunsaturated mediators and G-protein coupled receptor-signaling pathways. These enzymatically oxygenated polyunsaturated fatty acids belong to distinct families of specialized pro-resolving autacoids. The protectin family of mediators has attracted an interest because of their potent pro-resolving and anti-inflammatory actions verified in several in vivo disease models. Herein, we present the stereoselective synthesis and biological evaluations of 3-oxa-PD1n-3 DPA, a protectin D1 analog. Results from mouse models indicate that the mediators protectin D1, PD1n-3 DPA and the new analog 3-oxa-PD1n-3 DPA all relieved streptozotocin-induced diabetic neuropathic pain at doses of 90 and 300 pmol, equivalent to 30 and 100 ng, respectively, following intrathecal (I.T.) injection. Of interest, at a low dose of only 30 pmol (10 ng; I.T.) only 3-oxa PD1n-3 DPA was able to alleviate neuropathic pain, directly compared to vehicle controls. Moreover, using a chronic itch model of cutaneous T-cell lymphoma (CTCL), all three compounds at 300 pmol (100 ng) showed a significant reduction in itching for several hours. The biomolecular information on the structure-functions of the protectins and the new synthetic analog 3-oxa-PD1n-3 DPA is of interest towards developing new immunoresolvents.

Bidragsytere

Jannicke Irina Nesman

  • Tilknyttet:
    Forfatter
    ved Seksjon for farmasøytisk kjemi ved Universitetet i Oslo

Ouyang Chen

  • Tilknyttet:
    Forfatter
    ved Duke University

Xin Luo

  • Tilknyttet:
    Forfatter
    ved Duke University

Ru-Rong Ji

  • Tilknyttet:
    Forfatter
    ved Duke University

Charles N. Serhan

  • Tilknyttet:
    Forfatter
    ved Harvard Medical School
  • Tilknyttet:
    Forfatter
    ved Brigham and Women's Hospital
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