Cristin-resultat-ID: 2027260
Sist endret: 20. februar 2023, 14:10
NVI-rapporteringsår: 2022
Resultat
Vitenskapelig artikkel
2022

SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells

Bidragsytere:
  • Quirin Hammer
  • Josefine Dunst
  • Wanda Christ
  • Francesca Picarazzi
  • Mareike Wendorff
  • Pouria Momayyezi
  • mfl.

Tidsskrift

Cell reports
ISSN 2211-1247
e-ISSN 2211-1247
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2022
Publisert online: 2022
Volum: 38
Hefte: 10
Artikkelnummer: 110503
Open Access

Importkilder

Scopus-ID: 2-s2.0-85125530610

Beskrivelse Beskrivelse

Tittel

SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells

Sammendrag

Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in patients with acute coronavirus disease 2019 (COVID-19). However, by which mechanisms NK cells detect SARS-CoV-2-infected cells remains largely unknown. Here, we show that the Non-structural protein 13 of SARS-CoV-2 encodes for a peptide that is presented by human leukocyte antigen E (HLA-E). In contrast with self-peptides, the viral peptide prevents binding of HLA-E to the inhibitory receptor NKG2A, thereby rendering target cells susceptible to NK cell attack. In line with these observations, NKG2A-expressing NK cells are particularly activated in patients with COVID-19 and proficiently limit SARS-CoV-2 replication in infected lung epithelial cells in vitro. Thus, these data suggest that a viral peptide presented by HLA-E abrogates inhibition of NKG2A+ NK cells, resulting in missing self-recognition.

Bidragsytere

Quirin Hammer

  • Tilknyttet:
    Forfatter
    ved Karolinska Institutet
  • Tilknyttet:
    Forfatter
    ved Karolinska Universitetssjukhuset

Josefine Dunst

  • Tilknyttet:
    Forfatter
    ved Karolinska Institutet
  • Tilknyttet:
    Forfatter
    ved Karolinska Universitetssjukhuset

Wanda Christ

  • Tilknyttet:
    Forfatter
    ved Karolinska Universitetssjukhuset
  • Tilknyttet:
    Forfatter
    ved Karolinska Institutet

Francesca Picarazzi

  • Tilknyttet:
    Forfatter
    ved Università degli Studi di Siena

Mareike Wendorff

  • Tilknyttet:
    Forfatter
    ved Christian-Albrechts-Universität zu Kiel
1 - 5 av 51 | Neste | Siste »