Sammendrag
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with a variety of symptoms such as post-exertional
malaise, fatigue, and pain, but where aetiology and pathogenesis are unknown. An increasing number of studies have implicated
the involvement of the immune system in ME/CFS. Furthermore, a hereditary component is suggested by the reported increased
risk for disease in relatives, and genetic association studies are being performed to identify potential risk variants. We recently
reported an association with the immunologically important human leucocyte antigen (HLA) genes HLA-C and HLA-DQB1 in ME/
CFS. Furthermore, a genome-wide genetic association study in 42 ME/CFS patients reported significant association signals with two
variants in the T cell receptor alpha (TRA) locus (P value
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