Cristin-resultat-ID: 2145189
Sist endret: 10. mai 2023, 13:24
NVI-rapporteringsår: 2023
Resultat
Vitenskapelig artikkel
2023

Non-synonymous variation and protein structure of candidate genes associated with selection in farm and wild populations of turbot (Scophthalmus maximus)

Bidragsytere:
  • Øivind Andersen
  • Juan Andrés Rubiolo
  • Davide Pirolli
  • Oscar Aramburu
  • Marina Pampín
  • Benedetta Righino
  • mfl.

Tidsskrift

Scientific Reports
ISSN 2045-2322
e-ISSN 2045-2322
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2023
Volum: 13
Hefte: 1
Sider: 1 - 16
Artikkelnummer: 3019
Open Access

Importkilder

Scopus-ID: 2-s2.0-85148549419

Beskrivelse Beskrivelse

Tittel

Non-synonymous variation and protein structure of candidate genes associated with selection in farm and wild populations of turbot (Scophthalmus maximus)

Sammendrag

Non-synonymous variation (NSV) of protein coding genes represents raw material for selection to improve adaptation to the diverse environmental scenarios in wild and livestock populations. Many aquatic species face variations in temperature, salinity and biological factors throughout their distribution range that is reflected by the presence of allelic clines or local adaptation. The turbot (Scophthalmus maximus) is a flatfish of great commercial value with a flourishing aquaculture which has promoted the development of genomic resources. In this study, we developed the first atlas of NSVs in the turbot genome by resequencing 10 individuals from Northeast Atlantic Ocean. More than 50,000 NSVs where detected in the ~ 21,500 coding genes of the turbot genome, and we selected 18 NSVs to be genotyped using a single Mass ARRAY multiplex on 13 wild populations and three turbot farms. We detected signals of divergent selection on several genes related to growth, circadian rhythms, osmoregulation and oxygen binding in the different scenarios evaluated. Furthermore, we explored the impact of NSVs identified on the 3D structure and functional relationship of the correspondent proteins. In summary, our study provides a strategy to identify NSVs in species with consistently annotated and assembled genomes to ascertain their role in adaptation.

Bidragsytere

Øivind Andersen

  • Tilknyttet:
    Forfatter
    ved Produksjonsbiologi ved NOFIMA
  • Tilknyttet:
    Forfatter
    ved Institutt for husdyr- og akvakulturvitenskap ved Norges miljø- og biovitenskapelige universitet

Juan Andrés Rubiolo

  • Tilknyttet:
    Forfatter
    ved Universidad de Santiago de Compostela

Davide Pirolli

  • Tilknyttet:
    Forfatter
    ved Consiglio Nazionale delle Ricerche

Oscar Aramburu

  • Tilknyttet:
    Forfatter
    ved Universidad de Santiago de Compostela

Marina Pampín

  • Tilknyttet:
    Forfatter
    ved Universidad de Santiago de Compostela
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