Sammendrag
Background The cereal fbre β-glucan reduces postprandial glycaemia, however, the underlying mechanisms are
not fully understood. Thus, the aim of this study was to investigate the acute efect of a β-glucan-enriched oat bread
on gastric emptying half-time (T1/2), gastric emptying lag phase (Tlag), and gastric emptying rate (GER), and the secre‑
tion of glucagon-like peptide-1 (GLP-1) as potential means to infuence postprandial glycaemia.
Methods A randomised crossover trial was conducted in 22 healthy adults (age 24.6±3.1 years, BMI 23.1±2.7 kg/m2
)
receiving 25 g available carbohydrates from a β-glucan-enriched oat bread or a control whole-wheat bread at two
non-consecutive days. T1/2, Tlag, and GER were determined based on ultrasound measures of the cross-sectional gas‑
tric antrum area in the fasting state and 15, 30, 45, 60, 90, and 120 min postprandially. Capillary glucose, serum insulin,
and plasma GLP-1 concentrations were measured at the same time points.
Results A biphasic pattern of gastric emptying with a distinct Tlag before the commencement of emptying
was observed in most subjects for both bread types. While no diferences in GER were evident (p=0.562), consump‑
tion of the oat bread signifcantly increased T1/2 by 18 min and Tlag by 14 min compared with the whole-wheat bread
(p=0.005 and p=0.010, respectively). In addition, the oat bread signifcantly reduced iAUC2h for glucose and insulin
responses compared with the whole-wheat bread (p=0.001 and p
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