Cristin-resultat-ID: 2264941
Sist endret: 3. juni 2024, 10:21
NVI-rapporteringsår: 2024
Resultat
Vitenskapelig artikkel
2024

New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project

Bidragsytere:
  • Igor Snapkov
  • Nicola Margareta Smith
  • Emma Arnesdotter
  • Karsten Beekmann
  • Etienne B. Blanc
  • Albert Braeuning
  • mfl.

Tidsskrift

Frontiers in Toxicology
e-ISSN 2673-3080
NVI-nivå 1

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2024
Volum: 6
Artikkelnummer: 1339104
Open Access

Importkilder

Scopus-ID: 2-s2.0-85191031759

Beskrivelse Beskrivelse

Tittel

New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project

Sammendrag

As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms, resulting in immunosuppression, hypersensitivity, increased risk of autoimmune diseases and cancer development. At present, the regulatory assessment of the immunotoxicity of chemicals relies heavily on rodent models and a limited number of Organisation for Economic Co-operation and Development (OECD) test guidelines, which only capture a fraction of potential toxic properties. Due to this limitation, various authorities, including the World Health Organization and the European Food Safety Authority have highlighted the need for the development of novel approaches without the use of animals for immunotoxicity testing of chemicals. In this paper, we present a concise overview of ongoing efforts dedicated to developing and standardizing methodologies for a comprehensive characterization of the immunotoxic effects of chemicals, which are performed under the EU-funded Partnership for the Assessment of Risk from Chemicals (PARC).

Bidragsytere

Igor Snapkow

Bidragsyterens navn vises på dette resultatet som Igor Snapkov
  • Tilknyttet:
    Forfatter
    ved Avdeling for kjemikalietoksikologi ved Folkehelseinstituttet

Nicola Margareta Smith

  • Tilknyttet:
    Forfatter
    ved Avdeling for kjemikalietoksikologi ved Folkehelseinstituttet

Emma Arnesdotter

  • Tilknyttet:
    Forfatter
    ved Luxembourg Institute of Science and Technology

Karsten Beekmann

  • Tilknyttet:
    Forfatter
    ved Wageningen University & Research

Etienne B. Blanc

  • Tilknyttet:
    Forfatter
    ved Institut National de la Santé et de la recherche médicale
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