Sammendrag
Background: Data from some population-based studies have indicated an increased risk of atrial fibrillation (AF) among
patients with migraine, particularly among individuals with migraine with aura. The present study aimed to assess the association
between primary headache disorders and AF.
Methods: In a population-based 9-year follow-up design, we evaluated the questionnaire-based headache diagnosis,
migraine and tension-type headache (TTH) included, collected in the Trøndelag Health Study (HUNT3) conducted in
2006–2008, and the subsequent risk of AF in the period until December 2015. The population at risk consisted of
39,340 individuals ≥20 years without AF at HUNT3 baseline who answered headache questionnaire during HUNT3.
The prospective association was evaluated by multivariable Cox proportional hazard models with 95% confidence intervals
(CIs).
Results: Among the 39,340 participants, 1524 (3.8%) developed AF during the 9-year follow up, whereof 91% of these
were ≥55 years. In the multivariable analyses, adjusting for known confounders, we did not find any association between
migraine or TTH and risk of AF. The adjusted hazard ratios (HRs) were respectively 0.84 (95% CI = 0.64–1.11) for
migraine, 1.16 (95% CI = 0.86–1.27) for TTH and 1.04 (95% CI = 0.86–1.27) for unclassified headache. However, in sensitivity
analyses of individuals aged ≥55 years, a lower risk of AF was found for migraine (HR = 0.53; 95% CI = 0.39–0.73).
Conclusions: In this large population-based study, no increased risk of AF was found among individuals with migraine or
TTH at baseline. Indeed, among individuals aged ≥55 years, migraine was associated with a lower risk for AF.
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