Sammendrag
Our labs introduced methods that are able to
assess regional myocardial function, from volumetric ultrasound
data. Burdock estimates myocardial deformation using a 3D
speckle-tracking approach, while splineMIRIT is a B-spline
transformation-based elastic registration method. The aim of the
present study was to test and contrast the diagnostic accuracy of
both approaches in the clinical setting. Furthermore, the manual
initialization step, required by both methods, was replaced by
using RCTL, a real time tracking, fully automatic library that
provided the initial geometry of the left ventricle.
Volumetric ultrasound data was acquired in a total of 12
healthy volunteers and 13 patients with proven coronary artery
disease. The acquired data was divided in two subgroups.
For the first, wall motion scoring (WMS) (0=normo-kinetic;
1=hypo-kinetic; 2=a-kinetic; 3=dys-kinetic), 3D image quality (0
= good, 1 = reasonable, 2 = poor, 3= unacceptable) as well as
tracking quality (0=bad; 1=good) using three standard apical
views and 3 short axis slices at different levels in the LV were
recorded on a segmental basis by a trained cardiologist blinded
to the data and compared among methods. Their ability to
detect infarcted patients was tested by computing per patient
sensitivity and specificity values (WMS as reference). For the
second group segmental longitudinal strain values were computed
using a commercially available package as well as Burdock and
splineMIRIT. Differences in normal and unhealthy segments of
high 3D quality were compared.
Tracking quality was better for splineMIRIT (85% vs. 79%
of segments), however Burdock achieved better detection of MI
cases (sensitivity 70% vs. 40%, specificity 81.82% vs. 90.91%).
In addition, the ANOVA test yielded significant differences,
in segmental longitudinal stain, among normal and abnormal
segments for both methods (p-value
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