Properties and Functions of Human Uracil-DNA Glycosylase from the UNG Gene

The human UNG-gene at position 12q24.1 encodes nuclear UNG2 and m itochondrial UNG 1 forms of uracil DNA glycosylase using differentially regulated promotoers, Pa and Pb and alternative splicing to produce two proteins with unique N terminal sorting sequences. PCNA and RPA co-localize with UNG2. Mitochondrial UNG1 is processed to shorter forms by mitoochondrial processing peptidase MPP and an unidentified mitochondrial protease. The common core catalytic domain in UNG1 and UNG2 cibtaubs a cibserved DBA binding groove and a tight.fitting uracil-binding pocket that binds uracil only when the uracil containing nucleotide is flipping out.