Cristin-prosjekt-ID: 2509342
Sist endret: 22. april 2021, 09:24

Cristin-prosjekt-ID: 2509342
Sist endret: 22. april 2021, 09:24
Prosjekt

Har kvinners vitamin D status i svangerskapet betydning for barnas senere helse?

prosjektleder

Anne Lise Brantsæter
ved Smittevern ved Folkehelseinstituttet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Göteborgs universitet

Klassifisering

Emneord

Vitamin D • Barn • Svangerskap • Vekst

Tidsramme

Aktivt
Start: 2. september 2019 Slutt: 23. desember 2022

Beskrivelse Beskrivelse

Tittel

Har kvinners vitamin D status i svangerskapet betydning for barnas senere helse?

Populærvitenskapelig sammendrag

Lavt vitamin D inntak og status i svangerskapet kan via programmering i fosterlivet ha negativ innvirkning på barns vekst og senere helse. Studier antyder en sammenheng mellom lavt vitamin D status og vektutvikling hos barn, men høyere forekomst av overvekt og dårligere kardiometabolsk helse. Lav vitamin D status i svangerskapet er vanlig, spesielt blant grupper minoritetsbakgrunn eller lav utdanning. Det er behov for store studier for å belyse mulige effekter av lavt vitamin D inntak i svangerskapet og vekst og helseutfall hos barna. Målet med denne studien er å teste hypotesen om at lavt inntak av vitamin D og lav vitamin D status i svangerskapet påvirker barns vekst og vektutvikling og kan føre til fedme og ugunstig kardiometabolsk risiko-profil.

Tittel

May maternal vitamin D status in pregnancy relate to children´s later health?

Populærvitenskapelig sammendrag

Prevalences of cardiometabolic disorders and obesity are rapidly increasing. This trend indicates that the probability of reaching the World health organization (WHO) global obesity target, of no rise in obesity by 2025, is close to zero. In 2014, an estimated 41 million children under 5 years of age were affected by overweight or obesity. Thus, also childhood obesity has reached alarming proportions. Growth in early childhood is an important determinant of risk of obesity and adverse cardiometabolic profile in childhood and during the life course. Childhood obesity overlaps with indicators of cardiometabolic disorders, and associates with higher prevalence of comorbidities and higher mortality rates in adulthood. Although, signs of levelling off in some setting, childhood obesity is still increasing in disadvantaged segments of many populations including the Nordic. Thus, there is an urgent need to tackle the development of childhood obesity and to identify prevention strategies to combat childhood obesity and its comorbidities, including cardiometabolic risk profiles. WHO points out, that considerations of exposures in the environment throughout the life-course are required, and that pregnancy is regarded as a critical period in this context. Appetite and long-term regulation of energy balance in the offspring may be permanently programmed by the environment in utero during pregnancy, which may influence lifelong consequences for health. Thus, pregnancy may be crucial for preventive strategies to combat childhood obesity and cardiometabolic disorders and promote health of the next generation. Poor maternal vitamin D status in pregnancy has been identified as a potential modifiable early-life risk factor for prevention of obesity development and adverse cardiometabolic profile. Nevertheless, the evidence of the adverse effects of poor maternal vitamin D status remains insufficient, and the effects on childhood growth beyond infancy are largely unknown. We know though that poor vitamin D status may occur during winter and among those with low vitamin D intake. Additionally, vitamin D deficiency is especially common among ethnic minorities at Northern latitudes. Mother and child cohorts are ideal to study exposure-outcome associations, because of the extensive assessment of socioeconomic, health and lifestyle factors. We aim to test the hypothesis that low maternal vitamin D intake and poor vitamin D status may affect growth and increase the obesity risk throughout childhood, resulting in an unfavorable cardiometabolic profile.Two cohorts will be included
1) the Norwegian Mother, Father and Child Cohort Study (MoBa), with
95 200 women and children to 13/14 years; and 2) the multi-Page 8 of 13 ethnic Swedish Mother- and Child cohort (GraviD-child), with 2125 women and children to 5 years.
The specific aims are to study:1. The association between maternal intake of vitamin D and growth throughout childhood and obesity risk in children (n~80000 mother-child pairs, MoBa). 2. The association between maternal vitamin D status (serum 25-hydroxyvitamin D, 25OHD) and growth in childhood and obesity risk in children (n~3000 mother-child pairs MoBa and n~2000 mother-child pairs GraviD-child).
3. The association between maternal vitamin D status and child cardiometabolic risk profile (n~700 mother-child pairs, MoBa).
4. If associations are observed from the previous aims, we will further explore the biological pathway through which maternal vitamin D status during pregnancy can program later excess weight gain as part of an unfavorable cardiometabolic profile in children by:
i. Studying the hypothesis of an inflammatory pathway that might mediate the association between maternal vitamin D status and growth in childhood and obesity risk in children. ii. Studying the hypothesis of impaired maternal glucose metabolism and stress might mediate the observed association with child´s weight.

prosjektdeltakere

prosjektleder

Anne Lise Brantsæter

  • Tilknyttet:
    Prosjektleder
    ved Smittevern ved Folkehelseinstituttet

Anna Amberntsson

  • Tilknyttet:
    Prosjektdeltaker
    ved Göteborgs universitet

Linnea Bärebring

  • Tilknyttet:
    Prosjektdeltaker
    ved Göteborgs universitet

Hanna Augustin

  • Tilknyttet:
    Prosjektdeltaker
    ved Göteborgs universitet

Eleni Zoumpoulia Papadopoulou

  • Tilknyttet:
    Prosjektdeltaker
    ved Smittevern ved Folkehelseinstituttet
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