Cristin-prosjekt-ID: 432016
Sist endret: 17. desember 2015, 13:50

Cristin-prosjekt-ID: 432016
Sist endret: 17. desember 2015, 13:50
Prosjekt

Gastrointestinal quality of life, reflux disease and motility disorders in patients with morbid obesity and diabetes selected for bariatric surgery

prosjektleder

Birgitte Karen Berggreen Seip
ved Medisinsk klinikk ved Sykehuset i Vestfold HF

prosjekteier / koordinerende forskningsansvarlig enhet

  • Medisinsk klinikk ved Sykehuset i Vestfold HF

Tidsramme

Avsluttet
Start: 1. januar 2013 Slutt: 31. desember 2019

Beskrivelse Beskrivelse

Tittel

Gastrointestinal quality of life, reflux disease and motility disorders in patients with morbid obesity and diabetes selected for bariatric surgery

Vitenskapelig sammendrag

About 2 % of the Norwegian adult population suffers from morbid obesity. Due to limited long-term weight loss after non-surgical treatment, various surgical techniques (bariatric surgery) have been developed. The Roux-en-Y gastric bypass, a combined restrictive and malabsorptive procedure, is the most commonly performed bariatric procedure both in Norway and worldwide. Vertical (sleeve) gastrectomy is a purely restrictive procedure. In the “Obesity Surgery in Tønsberg-study” (OSEBERG-study) patients with morbid obesity and type 2 diabetes are randomized to either gastric bypass or sleeve gastrectomy.   

The primary outcome of the OSEBERG-study is beta-cell function and glycemic control one year post operation. The participants in OSEBERG have severe obesity and type 2 diabetes. Both diseases are associated with impaired quality of life, impaired gastrointestinal quality of life and a high prevalence of gastroesophageal reflux disease (GERD) and esophageal motility disorders. The physiological mechanisms explaining gastrointestinal symptoms in subjects with obesity and/or diabetes are, however, poorly understood. One major concern related to sleeve gastrectomy is the increased risk for gastroesophageal reflux disease (GERD) following the operation. The effect of sleeve gastrectomy on GERD remains controversial, and studies addressing both objective and subjective measures of GERD are needed.

The main aim of the present randomized controlled study (OSEBERG Reflux) is to compare the long-term (1-year) effects of gastric bypass and sleeve gastrectomy on postoperative GERD symptoms and objective findings. The secondary aims are, first, to increase the understanding of how gastrointestinal quality of life, GERD and motility disorders are affected by type 2 diabetes in severely obese patients, and, second, to assess the extent to which subjective symptoms correlate with the objective endoscopic findings of GERD and esophageal motility disorders.  

prosjektdeltakere

prosjektleder

Birgitte Karen Berggreen Seip

  • Tilknyttet:
    Prosjektleder
    ved Medisinsk klinikk ved Sykehuset i Vestfold HF

Jolanta Halabowska Lorentzen

  • Tilknyttet:
    Prosjektdeltaker
    ved Medisinsk klinikk ved Sykehuset i Vestfold HF

Dag Hofsø

  • Tilknyttet:
    Prosjektdeltaker
    ved Medisinsk klinikk ved Sykehuset i Vestfold HF

Rune Sandbu

  • Tilknyttet:
    Prosjektdeltaker
    ved Kirurgisk klinikk ved Sykehuset i Vestfold HF
Aktiv cristin-person

Jøran Sture Hjelmesæth

  • Tilknyttet:
    Prosjektdeltaker
    ved Medisinsk klinikk ved Sykehuset i Vestfold HF
  • Tilknyttet:
    Prosjektdeltaker
    ved Endokrinologisk avdeling ved Universitetet i Oslo
1 - 5 av 6 | Neste | Siste »

Resultater Resultater

Esophageal motility in morbidly obese patients with type 2 diabetes.

Lorentzen, Jolanta; Medhus, Asle Wilhelm; Hjelmesæth, Jøran; Hofsø, Dag; Karlsen, Tor-Ivar; Sandbu, Rune; Seip, Birgitte Karen Berggreen. 2015, United European Gastroenterology Week. VESTFOLD, UIO, OUSPoster

Questionnaires may be insufficient to diagnose gastroesophageal reflux disease (GERD) in morbidly obese patients with type 2 diabetes.

Lorentzen, Jolanta; Hjelmesæth, Jøran; Medhus, Asle Wilhelm; Hofsø, Dag; Karlsen, Tor-Ivar; Sandbu, Rune; Seip, Birgitte Karen Berggreen. 2015, United European Gastroenterology Week. VESTFOLD, UIO, OUSPoster
1 - 2 av 2