Background. For the first time, short- and long-term effects of a multi-site randomized-controlled trial (RCT) of video feedback of infant–parent interaction intervention (VIPI) is conducted. Video feedback interventions are widely implemented in Scandinavia. The VIPI targets families with children younger than 2 years old and parent–child interaction problems. Outcome variables in this study are 1) observed parent–infant interaction and 2) parent-reported child social and emotional development. Between-group differences of the moderating effects of parental symptoms of depression, personality disorder traits, and demographic variables are investigated. Method: The study has a parallel group, consecutively randomized single-blinded design; participants are recruited by health- and social workers.Seventy-five families receive VIPI, and 57 families receive treatment as usual (TAU). Videotapes of each parent–infant interaction are obtained before treatment, right after treatment, and at a 6-month follow-up, and are coded according to Biringen’s Emotional Availability Scales. Parental symptoms of depression and personality disorder traits are included as possible moderators.