Cristin-resultat-ID: 1064839
Sist endret: 12. november 2013 11:30
Resultat
Sammendrag/abstract
2013

Low serum concentration of vitamin E is associated with increased risk of hip fracture in the elderly. A NOREPOS case-cohort study

Bidragsytere:
  • Kristin Holvik
  • Clara Gram Gjesdal
  • Grethe S Tell
  • Guri Grimnes
  • Ellen M Apalset
  • Berit Schei
  • mfl.

Tidsskrift

Journal of Bone and Mineral Research
ISSN 0884-0431
e-ISSN 1523-4681
NVI-nivå 2

Om resultatet

Sammendrag/abstract
Publiseringsår: 2013
Publisert online: 2013
Volum: 28
Sider: S63
Artikkelnummer: FR0315

Beskrivelse Beskrivelse

Tittel

Low serum concentration of vitamin E is associated with increased risk of hip fracture in the elderly. A NOREPOS case-cohort study

Sammendrag

The increased oxidative stress associated with ageing influences the formation and survival of bone forming and bone resorbing cells. Vitamin E, of which α-tocopherol is the most abundant form in human tissues, is a plant-derived lipid soluble substance with potent antioxidant properties. The relation between vitamin E concentrations in blood and risk of hip fracture has not previously been investigated in a population-based study. We aimed to study the association between α-tocopherol levels in serum and risk of hip fractures in elderly men and women in Norway, the population with the world’s highest hip fracture incidence. In the Norwegian Epidemiologic Osteoporosis Studies (NOREPOS), we performed a case-cohort analysis in 21,774 men and women aged 65-79 years (mean 72 y) who underwent baseline examinations in four population-based health studies during 1994-2001. Data on incident hip fractures occurring up to 10.7 years of follow-up were retrieved from electronic patient administrative systems. Frozen serum samples from baseline were analyzed in participants who suffered a hip fracture during follow-up (n=1179; 307 men and 872 women) and in sex-stratified random samples from baseline (n=1447, including 89 of those who later suffered a hip fracture). α-tocopherol in serum was determined by high pressure liquid chromatography (HPLC)-fluorescence detection. Cox proportional hazards regression adapted for the case-cohort design was performed with adjustment for age, sex, and study center. Median (25, 75-percentile) serum α-tocopherol concentration was 30.0 (22.6, 38.3) µmol/l. A linear inverse relation between serum α-tocopherol levels and hip fracture was observed, with hazard ratio (HR) 1.12 (95% CI 1.04-1.20) per 10 µmol/l lower serum α-tocopherol. HR of hip fracture in the lowest (=38.3 µmol/l) quartile of serum α-tocopherol was 1.53 (95% CI 1.18-1.97). The trend was linear across quartiles (p

Bidragsytere

Aktiv cristin-person

Kristin Holvik

  • Tilknyttet:
    Forfatter
    ved Avdeling for kroniske sykdommer og aldring ved Folkehelseinstituttet

Clara Gram Gjesdal

  • Tilknyttet:
    Forfatter
    ved Revmatologisk avdeling ved Helse Bergen HF - Haukeland universitetssykehus
  • Tilknyttet:
    Forfatter
    ved Institutt for klinisk medisin ved Universitetet i Bergen

Grethe Seppola Tell

Bidragsyterens navn vises på dette resultatet som Grethe S Tell
  • Tilknyttet:
    Forfatter
    ved Institutt for global helse og samfunnsmedisin ved Universitetet i Bergen

Guri Grimnes

  • Tilknyttet:
    Forfatter
    ved Endokrinologi ved UiT Norges arktiske universitet

Ellen Margrete Apalset

Bidragsyterens navn vises på dette resultatet som Ellen M Apalset
  • Tilknyttet:
    Forfatter
    ved Revmatologisk avdeling ved Helse Bergen HF - Haukeland universitetssykehus
  • Tilknyttet:
    Forfatter
    ved Institutt for global helse og samfunnsmedisin ved Universitetet i Bergen
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