Cristin-resultat-ID: 1620208
Sist endret: 24. januar 2019, 15:52
NVI-rapporteringsår: 2018
Resultat
Vitenskapelig artikkel
2018

Inactivated Piscine orthoreovirus vaccine protects against heart and skeletal muscle inflammation in Atlantic salmon

Bidragsytere:
  • Øystein Wessel
  • Øyvind Haugland
  • Marit Rode
  • Børge Nilsen Fredriksen
  • Maria Dahle og
  • Espen Rimstad

Tidsskrift

Journal of Fish Diseases
ISSN 0140-7775
e-ISSN 1365-2761
NVI-nivå 2

Om resultatet

Vitenskapelig artikkel
Publiseringsår: 2018
Volum: 41
Hefte: 9
Sider: 1411 - 1419

Importkilder

Scopus-ID: 2-s2.0-85051781476

Beskrivelse Beskrivelse

Tittel

Inactivated Piscine orthoreovirus vaccine protects against heart and skeletal muscle inflammation in Atlantic salmon

Sammendrag

Heart‐ and skeletal muscle inflammation (HSMI) caused by infection with Piscine orthoreovirus (PRV) is one of the most common viral diseases in farmed Atlantic salmon (Salmo salar) in Norway, and disease outbreaks have been reported in most countries with large‐scale Atlantic salmon aquaculture. Currently there is no vaccine available for protection against HSMI, partly due to the lack of a cell line for efficient virus propagation. Erythrocytes are the primary target cells for PRV in vivo and a potential source for isolation of PRV particles. In this study, PRV was purified from infected erythrocytes, inactivated and used in a vaccination trial against HSMI. A single immunization with adjuvanted, inactivated PRV induced protection against HSMI in Atlantic salmon infected by virus injection 6 weeks later, while a moderate protection was obtained in fish infected through natural transmission, i.e. cohabitation. The PRV vaccine significantly reduced PRV loads and histopathological lesions typical for HSMI compared to the unvaccinated control group. This is the first demonstration of protective vaccination against PRV, and promising for future control of HSMI in Atlantic salmon aquaculture.

Bidragsytere

Øystein Wessel

  • Tilknyttet:
    Forfatter
    ved Institutt for prekliniske fag og patologi ved Norges miljø- og biovitenskapelige universitet

Øyvind Haugland

  • Tilknyttet:
    Forfatter
    ved Pharmaq AS

Marit Rode

  • Tilknyttet:
    Forfatter
    ved Pharmaq AS

Børge Fredriksen

Bidragsyterens navn vises på dette resultatet som Børge Nilsen Fredriksen
  • Tilknyttet:
    Forfatter
    ved Pharmaq AS
Aktiv cristin-person

Maria Dahle

  • Tilknyttet:
    Forfatter
    ved Forskningsgruppe fiskehelse ved Veterinærinstituttet
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