Cristin-prosjekt-ID: 2536830
Sist endret: 28. mars 2022, 14:04

Cristin-prosjekt-ID: 2536830
Sist endret: 28. mars 2022, 14:04
Prosjekt

Psychiatric Genetic Epidemiology (PaGE) group: Integrating causally informative designs and large data resources to understand the development of psychiatric disorders

prosjektleder

Alexandra Havdahl
ved Nic Waals Institutt ved Lovisenberg Diakonale Sykehus

prosjekteier / koordinerende forskningsansvarlig enhet

  • Lovisenberg Diakonale Sykehus

Finansiering

  • TotalbudsjettNOK 8.987.000
  • Helse Sør-Øst RHF
    Prosjektkode: 2020022

Klassifisering

Vitenskapsdisipliner

Utviklingspsykologi • Genetikk og genomikk • Psykiatri, barnepsykiatri • Epidemiologi medisinsk og odontologisk statistikk

Emneord

Alvorlige psykiske lidelser

HRCS-helsekategori

  • Generell helserelevans
  • Mental helse

HRCS-forskningsaktivitet

  • 1 Underbyggende Forskning
  • 2 Årsaksforhold

Kategorier

Prosjektkategori

  • Grunnforskning

Kontaktinformasjon

Sted
Alexandra Havdahl

Tidsramme

Aktivt
Start: 30. november 2020 Slutt: 31. desember 2025

Beskrivelse Beskrivelse

Tittel

Psychiatric Genetic Epidemiology (PaGE) group: Integrating causally informative designs and large data resources to understand the development of psychiatric disorders

Vitenskapelig sammendrag

Summary

Psychiatric disorders are highly heritable conditions constituting a leading cause of disability and impaired life quality. In spite of decades of research and interventions, knowledge about how psychiatric problems develop is still severely limited, and the burden is rising globally. Novel approaches are necessary to advance the field. The Helse Sør-Øst career grant will support Dr Havdahl in establishing the Psychiatric Genetic Epidemiology (PaGE) research group at Lovisenberg Diaconal Hospital. In PaGE, we are in a unique position to generate valuable insights by combining recent advancements across multiple disciplines, and by leveraging data from multiple population cohorts such as the Norwegian Mother, Father and Child Cohort (MoBa) of more than 200,000 participants. PaGE has the following core scientific objectives: 1) Elucidating how genetic risk for psychiatric disorder is expressed in early development, 2) Distinguishing genetic and environmental pathways of within-family transmission of psychiatric disorders, and 3) Identifying causal environmental risk and protective factors for psychiatric disorders. The career grant will facilitate the group achieving these objectives by supporting our implementation of causal methodologies, consolidating collaborations with international experts in the field, and recruiting a talented postdoctoral fellow, with skills complementary to the current members, to carry out novel analyses.

Primary and secondary objectives

Aim 1: Build PaGE into a robust, independent research group producing scientific outputs at the forefront of international research. Aim 2: Develop efficient workflows and analytic pipelines to facilitate an increasing number of publications and collaborations in each of the three core scientific objectives (provided in the summary above). Aim 3: Recruit a talented doctoral fellow to develop an analytic pipeline to optimize several different analyses which each makes use of the family structure within MoBa. 

prosjektdeltakere

prosjektleder
Aktiv cristin-person

Alexandra Havdahl

  • Tilknyttet:
    Prosjektleder
    ved Nic Waals Institutt ved Lovisenberg Diakonale Sykehus
  • Tilknyttet:
    Prosjektdeltaker
    ved Helse-, utviklings- og personlighetspsyk ved Universitetet i Oslo
  • Tilknyttet:
    Prosjektdeltaker
    ved Avdeling for psykiske lidelser ved Folkehelseinstituttet

Laura Hegemann

  • Tilknyttet:
    Prosjektdeltaker
    ved Nic Waals Institutt ved Lovisenberg Diakonale Sykehus
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Resultater Resultater

Common Genetic Variation And Age at Onset Of Anorexia Nervosa.

Watson, H; et, al.; Andreassen, Ole; Ask, Helga; et, al.; Havdahl, Alexandra; Et, Al.. 2021, biological psychiatry: global open science. FHI, LDS, UIOVitenskapelig artikkel

Intergenerational transmission of parental neuroticism to emotional problems in 8-year-old children: Genetic and environmental influences.

Ask, Helga; Eilertsen, Espen Moen; Gjerde, Line Cecilie; Hannigan, Laurie John; Gustavson, Kristin; Havdahl, Alexandra; Gillespie Cheesman, Rosa Catherine; McAdams, Tom A.; Hettema, John M.; Reichborn-Kjennerud, Ted mfl.. 2021, JCPP Advances. KCLUOL, USA, UoL, FHI, UoB, UIO, LDSVitenskapelig artikkel

Prenatal smoking, alcohol and caffeine exposure and maternal-reported attention deficit hyperactivity disorder symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses.

Haan, Elis; Sallis, Hannah M.; Zuccolo, Luisa; Labrecque, Jeremy; Ystrøm, Eivind; Reichborn-Kjennerud, Ted; Andreassen, Ole; Havdahl, Alexandra; Munafò, Marcus R.. 2021, Addiction. FHI, UoB, UIO, EMC, LDS, OUSVitenskapelig artikkel

The Lancet Commission on the future of care and clinical research in autism.

Lord, Catherine; Charman, Tony; Havdahl, Alexandra; Carbone, Paul; Anagnostou, Evdokia; Boyd, Brian; Carr, Themba; De Vries, Petrus J.; Dissanayake, Cheryl; Divan, Gauri mfl.. 2021, The Lancet. USA, PU, FHI, UCT, SMCoC, JWGFaM, STORBRITAN, RCHSD, ARGENTINA, LTU, UoCLA(, EU, UoK, KCLUOL, SANGATH, UoCD, NHS, UoU, LDS, UIO, UOT, YU, LSE, WHOVitenskapelig artikkel

The genomic basis of participation in the Norwegian Mother, Father and Child Cohort Study.

Hannigan, Laurie John; Corfield, Elizabeth; Biele, Guido; Tilling, Kate; McAdams, Tom A.; Badini, Isabella; Davey Smith, George; Richardson, Tom G.; Cornish, Rosie; Tesli, Martin Steen mfl.. 2021, Nordic Society of Human Genetics and Precision Medicine Conference 2021. FHI, UIO, LDS, OUS, UIBPoster
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