Cristin-prosjekt-ID: 2059160
Sist endret: 20. april 2020 13:06

Cristin-prosjekt-ID: 2059160
Sist endret: 20. april 2020 13:06
Prosjekt

EXIMIOUS - Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome

prosjektleder

Hubert Dirven
ved Folkehelseinstituttet

prosjekteier / koordinerende forskningsansvarlig enhet

  • Folkehelseinstituttet

Klassifisering

Vitenskapsdisipliner

Biofysikk • Generell immunologi • Medisinsk immunologi • Cellebiologi

Emneord

Eksponering • Blod • Kohortanalyse

Kategorier

Prosjektkategori

  • Anvendt forskning
  • Grunnforskning

Tidsramme

Aktivt
Start: 1. januar 2020 Slutt: 31. desember 2024

Beskrivelse Beskrivelse

Tittel

EXIMIOUS - Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome

Populærvitenskapelig sammendrag

"Immune-mediated, non-communicable diseases, such as autoimmune diseases, allergic diseases and asthma, are chronic disorders in which the interaction between exposome and immune system plays a pivotal role. As prevalence and societal costs of these diseases are rising in the EU, a holistic approach is needed. The EXIMIOUS consortium—gathering high-level experts in immunology, toxicology, clinical medicine, environmental hygiene, epidemiology, bioinformatics and sensor development—will bring about a new way of assessing the human exposome by linking innovative ways of characterizing and quantifying multiple and combined environmental exposures (exposomics) with high-dimensional immunophenotyping and -profiling platforms to map the (early) immune effects induced by these exposures (immunomics). In several cohorts—covering the entire lifespan, including prenatal life—we will extensively map exposome, immune system (immunome), other omics and clinical and socio-economic data, using two main methodologies—one starting from the exposome, the other starting from health effects—that ‘meet in the middle’. Novel bioinformatics tools, based on systems immunology and machine learning, will be used to integrate and analyse these huge datasets and to construct ‘immune fingerprints’ that reflect a person’s lifetime exposome and identify ‘immune fingerprints’ that are early signs of poor health and predictors of disease at the individual level. We will build a multifaceted toolbox for researchers, policy makers, clinicians and the general public containing the exposome/immunome tools developed during the project to help assess the impact of the exposome on the immune system at the level of individuals and populations. This will allow policy makers to grasp the components of the exposome that needs to be prioritized to be able to design targeted preventive policies to reduce healthcare and socioeconomic costs, leading to greater wellbeing for the EU population"

Vitenskapelig sammendrag

"Immune-mediated, non-communicable diseases, such as autoimmune diseases, allergic diseases and asthma, are chronic disorders in which the interaction between exposome and immune system plays a pivotal role. As prevalence and societal costs of these diseases are rising in the EU, a holistic approach is needed. The EXIMIOUS consortium—gathering high-level experts in immunology, toxicology, clinical medicine, environmental hygiene, epidemiology, bioinformatics and sensor development—will bring about a new way of assessing the human exposome by linking innovative ways of characterizing and quantifying multiple and combined environmental exposures (exposomics) with high-dimensional immunophenotyping and -profiling platforms to map the (early) immune effects induced by these exposures (immunomics). In several cohorts—covering the entire lifespan, including prenatal life—we will extensively map exposome, immune system (immunome), other omics and clinical and socio-economic data, using two main methodologies—one starting from the exposome, the other starting from health effects—that ‘meet in the middle’. Novel bioinformatics tools, based on systems immunology and machine learning, will be used to integrate and analyse these huge datasets and to construct ‘immune fingerprints’ that reflect a person’s lifetime exposome and identify ‘immune fingerprints’ that are early signs of poor health and predictors of disease at the individual level. We will build a multifaceted toolbox for researchers, policy makers, clinicians and the general public containing the exposome/immunome tools developed during the project to help assess the impact of the exposome on the immune system at the level of individuals and populations. This will allow policy makers to grasp the components of the exposome that needs to be prioritized to be able to design targeted preventive policies to reduce healthcare and socioeconomic costs, leading to greater wellbeing for the EU population"

Metode

I prosjektet brukes avanserte metoder for å studere eksposomet, immunomet og helseeffekter i ulike korhorter rundt i Europa. 

Utstyr

Massecytometer (CyTOF)

Flowcytometri

prosjektdeltakere

prosjektleder

Hubert Dirven

  • Tilknyttet:
    Prosjektleder
    ved Folkehelseinstituttet

Unni Cecilie Nygaard

  • Tilknyttet:
    Prosjektdeltaker
    ved Folkehelseinstituttet

Berit Brunstad Granum

  • Tilknyttet:
    Prosjektdeltaker
    ved Folkehelseinstituttet

Birgitte Lindeman

  • Tilknyttet:
    Prosjektdeltaker
    ved Folkehelseinstituttet

Nur Duale

  • Tilknyttet:
    Prosjektdeltaker
    ved Folkehelseinstituttet
1 - 5 av 6 | Neste | Siste »